Rotavirus disease in Guinea-Bissau, West Africa: a review of longitudinal community and hospital studies

Thea Kølsen Fischer, Peter Aaby, Kåre Mølbak, Amabélia Rodrigues

9 Citationer (Scopus)

Abstract

Rotavirus is one of the most common causes of childhood diarrheal disease and deaths in sub-Saharan Africa. This article reviews community- and hospital-based surveillance of rotavirus disease in Bissau, Guinea-Bissau, West Africa. Here, rotavirus infections exhibit a seasonal pattern, with annual epidemics occurring during the relatively dry and cooler months, from January to April, and few cases registered from May to December. Most children (74%) experience their first infection before the age of 2 years, and rotavirus has been identified as the most pathogenic of all diarrheal agents during 2 large prospective studies involving several hundred children <5 years of age. In the hospital setting, rotavirus accounts for a high case-fatality ratio (8%) and a high rate of nosocomial transmission; during the rotavirus season, 23% of all children admitted for nonrotavirus diarrheal disease acquired rotavirus infection during hospitalization (>48 h after admission).

OriginalsprogEngelsk
TidsskriftThe Journal of infectious diseases
Vol/bind202 Suppl
Sider (fra-til)S239-42
ISSN0022-1899
DOI
StatusUdgivet - 1 sep. 2010
Udgivet eksterntJa

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