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Room for improvement: Initiation of lipid lowering treatment and achievement of lipid target levels - a Danish registry-based study

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@article{4bca208b67f94c9dbdb1908373d38ab2,
title = "Room for improvement: Initiation of lipid lowering treatment and achievement of lipid target levels - a Danish registry-based study",
abstract = "AIMS: Prevention of adverse outcomes in individuals with high cholesterol levels may be improved by intensified lipid lowering treatment (LLT). We studied whether treatment goals of low density lipoprotein cholesterol (LDL-C) were reached within one year from baseline (defined as first LDL-C measurement) in a Danish population.METHODS AND RESULTS: Danish registries were used to identify all persons in the Northern Region of Denmark who had LDL-C measured between 1997-2012 and who were na{\"i}ve to LLT. Patients were categorized in LDL-C <5 or ≥ 5 mmol/L and further subdivided into low, high, and very high predicted cardiovascular (CV)-risk as suggested by European guidelines for risk stratification. Initiation of LLT and lipid target levels were assessed after one year (3.0, 2.5 and 1.8 mmol/L, respectively).In this study we examined the intensity of LLT and whether treatment goals were reached. More patients with LDL-C ≥5 mmol/L, regardless of the CV-risk, initiated LLT compared with patients who had a very high CV-risk and LDL-C <5 mmol/l. In total 37.7% (n = 32,581) of all patients with a follow-up LDL-C, and 25.1% (n = 3,229) of patients with LDL-C ≥5 mmol/l, had achieved their target levels after one year. Only 45.2% (n = 4,545) of the LDL-C ≥5 mmol/l high risk patients with a follow up LDL-C had started LLT 12 months after baseline.CONCLUSION: Less than half of patients presenting with an LDL-C ≥5 mmol/l start LLT within one year, representing a missed opportunity for both primary and secondary prevention of cardiovascular disease.",
keywords = "LDL cholesterol, Lipid-lowering treatment, Prevention",
author = "Rerup, {Sofie A} and Rasmus R{\o}rth and Bang, {Lia E} and Mogensen, {Ulrik M} and Christian Torp-Pedersen and Gunnar Gislason and Lars K{\o}ber and Fosb{\o}l, {Emil L}",
note = "Published on behalf of the European Society of Cardiology. All rights reserved. {\textcopyright} The Author(s) 2020. For permissions please email: journals.permissions@oup.com.",
year = "2021",
month = apr,
doi = "10.1093/ehjqcco/qcaa004",
language = "English",
volume = "7",
pages = "181--188",
journal = "European heart journal. Quality of care & clinical outcomes",
issn = "2058-5225",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Room for improvement

T2 - Initiation of lipid lowering treatment and achievement of lipid target levels - a Danish registry-based study

AU - Rerup, Sofie A

AU - Rørth, Rasmus

AU - Bang, Lia E

AU - Mogensen, Ulrik M

AU - Torp-Pedersen, Christian

AU - Gislason, Gunnar

AU - Køber, Lars

AU - Fosbøl, Emil L

N1 - Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions please email: journals.permissions@oup.com.

PY - 2021/4

Y1 - 2021/4

N2 - AIMS: Prevention of adverse outcomes in individuals with high cholesterol levels may be improved by intensified lipid lowering treatment (LLT). We studied whether treatment goals of low density lipoprotein cholesterol (LDL-C) were reached within one year from baseline (defined as first LDL-C measurement) in a Danish population.METHODS AND RESULTS: Danish registries were used to identify all persons in the Northern Region of Denmark who had LDL-C measured between 1997-2012 and who were naïve to LLT. Patients were categorized in LDL-C <5 or ≥ 5 mmol/L and further subdivided into low, high, and very high predicted cardiovascular (CV)-risk as suggested by European guidelines for risk stratification. Initiation of LLT and lipid target levels were assessed after one year (3.0, 2.5 and 1.8 mmol/L, respectively).In this study we examined the intensity of LLT and whether treatment goals were reached. More patients with LDL-C ≥5 mmol/L, regardless of the CV-risk, initiated LLT compared with patients who had a very high CV-risk and LDL-C <5 mmol/l. In total 37.7% (n = 32,581) of all patients with a follow-up LDL-C, and 25.1% (n = 3,229) of patients with LDL-C ≥5 mmol/l, had achieved their target levels after one year. Only 45.2% (n = 4,545) of the LDL-C ≥5 mmol/l high risk patients with a follow up LDL-C had started LLT 12 months after baseline.CONCLUSION: Less than half of patients presenting with an LDL-C ≥5 mmol/l start LLT within one year, representing a missed opportunity for both primary and secondary prevention of cardiovascular disease.

AB - AIMS: Prevention of adverse outcomes in individuals with high cholesterol levels may be improved by intensified lipid lowering treatment (LLT). We studied whether treatment goals of low density lipoprotein cholesterol (LDL-C) were reached within one year from baseline (defined as first LDL-C measurement) in a Danish population.METHODS AND RESULTS: Danish registries were used to identify all persons in the Northern Region of Denmark who had LDL-C measured between 1997-2012 and who were naïve to LLT. Patients were categorized in LDL-C <5 or ≥ 5 mmol/L and further subdivided into low, high, and very high predicted cardiovascular (CV)-risk as suggested by European guidelines for risk stratification. Initiation of LLT and lipid target levels were assessed after one year (3.0, 2.5 and 1.8 mmol/L, respectively).In this study we examined the intensity of LLT and whether treatment goals were reached. More patients with LDL-C ≥5 mmol/L, regardless of the CV-risk, initiated LLT compared with patients who had a very high CV-risk and LDL-C <5 mmol/l. In total 37.7% (n = 32,581) of all patients with a follow-up LDL-C, and 25.1% (n = 3,229) of patients with LDL-C ≥5 mmol/l, had achieved their target levels after one year. Only 45.2% (n = 4,545) of the LDL-C ≥5 mmol/l high risk patients with a follow up LDL-C had started LLT 12 months after baseline.CONCLUSION: Less than half of patients presenting with an LDL-C ≥5 mmol/l start LLT within one year, representing a missed opportunity for both primary and secondary prevention of cardiovascular disease.

KW - LDL cholesterol

KW - Lipid-lowering treatment

KW - Prevention

UR - http://www.scopus.com/inward/record.url?scp=85102964336&partnerID=8YFLogxK

U2 - 10.1093/ehjqcco/qcaa004

DO - 10.1093/ehjqcco/qcaa004

M3 - Journal article

C2 - 31958115

VL - 7

SP - 181

EP - 188

JO - European heart journal. Quality of care & clinical outcomes

JF - European heart journal. Quality of care & clinical outcomes

SN - 2058-5225

IS - 2

ER -

ID: 59053636