Role of TPMT and ITPA variants in mercaptopurine disposition

Keyphrases

• Thiopurine Methyltransferase 100%
• Mercaptopurine 100%
• Inosine Triphosphatase 100%
• DNA-TG 100%
• 6-mercaptopurine (6-MP) 50%
• Genotype 25%
• Erythrocytes 25%
• Childhood Acute Lymphoblastic Leukemia 25%
• Maintenance Therapy 25%
• 6-thioguanine nucleotides 25%
• Copenhagen 12%
• Blood Samples 12%
• Low Activity 12%
• Gene Variants 12%
• Dose Adjustment 12%
• Methotrexate 12%
• Metabolism 12%
• Methotrexate Treatment 12%
• Acute Lymphoblastic Leukemia 12%
• Methylated Metabolites 12%
• Treatment Intensity 12%
• Pharmacokinetic Parameters 12%
• Thioguanine 12%
• Plateaued 12%
• Thiopurine Metabolites 12%
• Methylase Genes 12%
• Nucleotide Metabolites 12%
• Rs1142345 12%
• Patient Median 12%
• Individual Dose 12%

Pharmacology, Toxicology and Pharmaceutical Science

• Thiopurine Methyltransferase 100%
• Mercaptopurine 100%
• Inosine 100%
• Erythromycin Ethylsuccinate 66%
• Tioguanine 50%
• Acute Lymphoblastic Leukemia 50%
• Methotrexate 33%
• Pharmacokinetic Parameter 16%

Biochemistry, Genetics and Molecular Biology

• Inosine Triphosphatase 100%