Role of nonalcoholic fatty liver disease in the development of insulin resistance and diabetes

Henning Grønbaek, Karen Louise Thomsen, Jørgen Rungby, Ole Schmitz, Hendrik Vilstrup

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a common disease that is usually accompanied by insulin resistance (IR). Whether or how NAFLD and IR are temporally and mechanistically related is controversial. Recent studies focus on their epidemiology, the importance of dietary fat, the role of adipocytokines and the sterol regulatory element-binding protein-1c. NAFLD and IR may progress to severe diseases, such as cirrhosis, diabetes or both, and understanding the pathogenesis of the precursor conditions has preventive and therapeutic implications. This review focuses on the possible relationships between NAFLD and IR and the treatment options available.
OriginalsprogEngelsk
TidsskriftExpert review of gastroenterology & hepatology
Vol/bind2
Udgave nummer5
Sider (fra-til)705-711
Antal sider7
ISSN1747-4124
DOI
StatusUdgivet - 2008

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