TY - JOUR
T1 - RNA profiling reveals familial aggregation of molecular subtypes in non-BRCA1/2 breast cancer families
AU - Larsen, Martin Jakob
AU - Thomassen, Mads
AU - Tan, Qihua
AU - Lænkholm, Anne-Vibeke
AU - Bak, Martin
AU - Sørensen, Kristina Pilekær
AU - Andersen, Mette Klarskov
AU - Kruse, Torben A
AU - Gerdes, Anne-Marie
PY - 2014
Y1 - 2014
N2 - In more than 70% of families with a strong history of breast and ovarian cancers, pathogenic mutation in BRCA1 or BRCA2 cannot be identified, even though hereditary factors are expected to be involved. It has been proposed that tumors with similar molecular phenotypes also share similar underlying pathophysiological mechanisms. In the current study, the aim was to investigate if global RNA profiling can be used to identify functional subgroups within breast tumors from families tested negative for BRCA1/2 germline mutations and how these subgroupings relate to different breast cancer patients within the same family.
AB - In more than 70% of families with a strong history of breast and ovarian cancers, pathogenic mutation in BRCA1 or BRCA2 cannot be identified, even though hereditary factors are expected to be involved. It has been proposed that tumors with similar molecular phenotypes also share similar underlying pathophysiological mechanisms. In the current study, the aim was to investigate if global RNA profiling can be used to identify functional subgroups within breast tumors from families tested negative for BRCA1/2 germline mutations and how these subgroupings relate to different breast cancer patients within the same family.
U2 - 10.1186/1755-8794-7-9
DO - 10.1186/1755-8794-7-9
M3 - Journal article
C2 - 24479546
SN - 1755-8794
VL - 7
SP - 9
JO - B M C Medical Genomics
JF - B M C Medical Genomics
IS - 1
ER -