RNA assemblages orchestrate complex cellular processes

Finn Cilius Nielsen, Heidi Theil Hansen, Jan Christiansen

20 Citationer (Scopus)

Abstract

Eukaryotic mRNAs are monocistronic, and therefore mechanisms exist that coordinate the synthesis of multiprotein complexes in order to obtain proper stoichiometry at the appropriate intracellular locations. RNA-binding proteins containing low-complexity sequences are prone to generate liquid droplets via liquid-liquid phase separation, and in this way create cytoplasmic assemblages of functionally related mRNAs. In a recent iCLIP study, we showed that the Drosophila RNA-binding protein Imp, which exhibits a C-terminal low-complexity sequence, increases the formation of F-actin by binding to 3' untranslated regions of mRNAs encoding components participating in F-actin biogenesis. We hypothesize that phase transition is a mechanism the cell employs to increase the local mRNA concentration considerably, and in this way synchronize protein production in cytoplasmic territories, as discussed in the present review.

OriginalsprogEngelsk
TidsskriftBioEssays
Vol/bind38
Udgave nummer7
Sider (fra-til)674-81
Antal sider8
ISSN0265-9247
DOI
StatusUdgivet - jul. 2016

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