Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

Demontis, D, Walters, RK, Rajagopal, VM, Waldman, ID, Grove, J, Als, TD, Dalsgaard, S, Ribasés, M, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Werge, T, Nordentoft, M, Mors, O, Mortensen, PB, ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Cormand, B, Hougaard, DM, Neale, BM, Franke, B, Faraone, SV, Børglum, AD & Steinhausen, H-C 2021, 'Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder', Nature Communications, bind 12, nr. 1, 576. https://doi.org/10.1038/s41467-020-20443-2

APA

Demontis, D., Walters, R. K., Rajagopal, V. M., Waldman, I. D., Grove, J., Als, T. D., Dalsgaard, S., Ribasés, M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Werge, T., Nordentoft, M., Mors, O., Mortensen, P. B., ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Cormand, B., Hougaard, D. M., Neale, B. M., Franke, B., ... Steinhausen, H-C. (2021). Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder. Nature Communications, 12(1), [576]. https://doi.org/10.1038/s41467-020-20443-2

CBE

Demontis D, Walters RK, Rajagopal VM, Waldman ID, Grove J, Als TD, Dalsgaard S, Ribasés M, Bybjerg-Grauholm J, Bækvad-Hansen M, Werge T, Nordentoft M, Mors O, Mortensen PB, ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Cormand B, Hougaard DM, Neale BM, Franke B, Faraone SV, Børglum AD, Steinhausen H-C. 2021. Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder. Nature Communications. 12(1):Article 576. https://doi.org/10.1038/s41467-020-20443-2

MLA

Vancouver

Author

Demontis, Ditte ; Walters, Raymond K ; Rajagopal, Veera M ; Waldman, Irwin D ; Grove, Jakob ; Als, Thomas D ; Dalsgaard, Søren ; Ribasés, Marta ; Bybjerg-Grauholm, Jonas ; Bækvad-Hansen, Maria ; Werge, Thomas ; Nordentoft, Merete ; Mors, Ole ; Mortensen, Preben Bo ; ADHD Working Group of the Psychiatric Genomics Consortium (PGC) ; Cormand, Bru ; Hougaard, David M ; Neale, Benjamin M ; Franke, Barbara ; Faraone, Stephen V ; Børglum, Anders D ; Steinhausen, Hans-Christoph. / Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder. I: Nature Communications. 2021 ; Bind 12, Nr. 1.

Bibtex

@article{1dc69a8995df48bb9358e57ca943dd92,
title = "Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder",
abstract = "Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10 −10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h 2 SNP = 0.34) when compared to ADHD without DBDs (h 2 SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (r g = 0.81) and anti-social behaviors (r g = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior. ",
keywords = "Attention Deficit Disorder with Hyperactivity/epidemiology, Attention Deficit and Disruptive Behavior Disorders/epidemiology, Child, China/epidemiology, Cohort Studies, Comorbidity, Europe/epidemiology, Female, Genetic Predisposition to Disease/genetics, Genome-Wide Association Study/methods, Humans, Male, Multifactorial Inheritance/genetics, Polymorphism, Single Nucleotide, Risk Factors",
author = "Ditte Demontis and Walters, {Raymond K} and Rajagopal, {Veera M} and Waldman, {Irwin D} and Jakob Grove and Als, {Thomas D} and S{\o}ren Dalsgaard and Marta Ribas{\'e}s and Jonas Bybjerg-Grauholm and Maria B{\ae}kvad-Hansen and Thomas Werge and Merete Nordentoft and Ole Mors and Mortensen, {Preben Bo} and {ADHD Working Group of the Psychiatric Genomics Consortium (PGC)} and Bru Cormand and Hougaard, {David M} and Neale, {Benjamin M} and Barbara Franke and Faraone, {Stephen V} and B{\o}rglum, {Anders D} and Hans-Christoph Steinhausen",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = dec,
doi = "10.1038/s41467-020-20443-2",
language = "English",
volume = "12",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

AU - Demontis, Ditte

AU - Walters, Raymond K

AU - Rajagopal, Veera M

AU - Waldman, Irwin D

AU - Grove, Jakob

AU - Als, Thomas D

AU - Dalsgaard, Søren

AU - Ribasés, Marta

AU - Bybjerg-Grauholm, Jonas

AU - Bækvad-Hansen, Maria

AU - Werge, Thomas

AU - Nordentoft, Merete

AU - Mors, Ole

AU - Mortensen, Preben Bo

AU - ADHD Working Group of the Psychiatric Genomics Consortium (PGC)

AU - Cormand, Bru

AU - Hougaard, David M

AU - Neale, Benjamin M

AU - Franke, Barbara

AU - Faraone, Stephen V

AU - Børglum, Anders D

A2 - Steinhausen, Hans-Christoph

N1 - Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/12

Y1 - 2021/12

N2 - Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10 −10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h 2 SNP = 0.34) when compared to ADHD without DBDs (h 2 SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (r g = 0.81) and anti-social behaviors (r g = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior.

AB - Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10 −10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h 2 SNP = 0.34) when compared to ADHD without DBDs (h 2 SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (r g = 0.81) and anti-social behaviors (r g = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior.

KW - Attention Deficit Disorder with Hyperactivity/epidemiology

KW - Attention Deficit and Disruptive Behavior Disorders/epidemiology

KW - Child

KW - China/epidemiology

KW - Cohort Studies

KW - Comorbidity

KW - Europe/epidemiology

KW - Female

KW - Genetic Predisposition to Disease/genetics

KW - Genome-Wide Association Study/methods

KW - Humans

KW - Male

KW - Multifactorial Inheritance/genetics

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

UR - http://www.scopus.com/inward/record.url?scp=85099802296&partnerID=8YFLogxK

U2 - 10.1038/s41467-020-20443-2

DO - 10.1038/s41467-020-20443-2

M3 - Journal article

C2 - 33495439

VL - 12

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 576

ER -

ID: 63734511