Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type

Birgitte Margareta Sode; Kristine H Allin; Morten Dahl; Finn Gyntelberg; Børge G Nordestgaard

doi:10.1503/cmaj.121636

Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type

Birgitte Margareta Sode, Kristine H Allin, Morten Dahl, Finn Gyntelberg, Børge G Nordestgaard

71 Citationer (Scopus)

Abstract

ABO blood type locus has been reported to be an important genetic determinant of venous and arterial thrombosis in genome-wide association studies. We tested the hypothesis that ABO blood type alone and in combination with mutations in factor V Leiden R506Q and prothrombin G20210A is associated with the risk of venous thromboembolism and myocardial infarction in the general population.

Originalsprog	Engelsk
Tidsskrift	C M A J
Vol/bind	185
Udgave nummer	5
Sider (fra-til)	E229-37
ISSN	0820-3946
DOI	https://doi.org/10.1503/cmaj.121636
Status	Udgivet - 19 mar. 2013

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title = "Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type",

abstract = "ABO blood type locus has been reported to be an important genetic determinant of venous and arterial thrombosis in genome-wide association studies. We tested the hypothesis that ABO blood type alone and in combination with mutations in factor V Leiden R506Q and prothrombin G20210A is associated with the risk of venous thromboembolism and myocardial infarction in the general population.",

keywords = "ABO Blood-Group System, Age Factors, Aged, Cohort Studies, Denmark, Factor V, Female, Genetic Predisposition to Disease, Genetic Testing, Humans, Incidence, Male, Middle Aged, Multivariate Analysis, Mutation, Myocardial Infarction, Polymorphism, Genetic, Proportional Hazards Models, Prothrombin, Retrospective Studies, Risk Assessment, Sex Factors, Statistics, Nonparametric, Survival Rate, Venous Thromboembolism",

author = "Sode, \{Birgitte Margareta\} and Allin, \{Kristine H\} and Morten Dahl and Finn Gyntelberg and Nordestgaard, \{B{\o}rge G\}",

year = "2013",

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day = "19",

doi = "10.1503/cmaj.121636",

language = "English",

volume = "185",

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journal = "C M A J",

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TY - JOUR

T1 - Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type

AU - Sode, Birgitte Margareta

AU - Allin, Kristine H

AU - Dahl, Morten

AU - Gyntelberg, Finn

AU - Nordestgaard, Børge G

PY - 2013/3/19

Y1 - 2013/3/19

N2 - ABO blood type locus has been reported to be an important genetic determinant of venous and arterial thrombosis in genome-wide association studies. We tested the hypothesis that ABO blood type alone and in combination with mutations in factor V Leiden R506Q and prothrombin G20210A is associated with the risk of venous thromboembolism and myocardial infarction in the general population.

AB - ABO blood type locus has been reported to be an important genetic determinant of venous and arterial thrombosis in genome-wide association studies. We tested the hypothesis that ABO blood type alone and in combination with mutations in factor V Leiden R506Q and prothrombin G20210A is associated with the risk of venous thromboembolism and myocardial infarction in the general population.

KW - ABO Blood-Group System

KW - Age Factors

KW - Aged

KW - Cohort Studies

KW - Denmark

KW - Factor V

KW - Female

KW - Genetic Predisposition to Disease

KW - Genetic Testing

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Mutation

KW - Myocardial Infarction

KW - Polymorphism, Genetic

KW - Proportional Hazards Models

KW - Prothrombin

KW - Retrospective Studies

KW - Risk Assessment

KW - Sex Factors

KW - Statistics, Nonparametric

KW - Survival Rate

KW - Venous Thromboembolism

UR - https://www.scopus.com/pages/publications/84875134556

U2 - 10.1503/cmaj.121636

DO - 10.1503/cmaj.121636

M3 - Journal article

C2 - 23382263

SN - 0820-3946

VL - 185

SP - E229-37

JO - C M A J

JF - C M A J

IS - 5

ER -

Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type

Abstract

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