Risk of triple-class virological failure in children with HIV: a retrospective cohort study

Hannah Castro, Ali Judd, Diana M Gibb, Karina Butler, Rebecca K Lodwick, Ard van Sighem, Jose T Ramos, Josiane Warsawski, Claire Thorne, Antoni Noguera-Julian, Niels Obel, Dominique Costagliola, Pat A Tookey, Céline Colin, Jesper Kjaer, Jesper Grarup, Genevieve Chene, Andrew Phillips, Pursuing Later Treatment Options II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE)

    88 Citationer (Scopus)

    Abstrakt

    In adults with HIV treated with antiretroviral drug regimens from within the three original drug classes (nucleoside or nucleotide reverse transcriptase inhibitors [NRTIs], non-NRTIs [NNRTIs], and protease inhibitors), virological failure occurs slowly, suggesting that long-term virological suppression can be achieved in most people, even in areas where access is restricted to drugs from these classes. It is unclear whether this is the case for children, the group who will need to maintain viral suppression for longest. We aimed to determine the rate and predictors of triple-class virological failure to the three original drugs classes in children.
    OriginalsprogEngelsk
    TidsskriftLancet
    Vol/bind377
    Udgave nummer9777
    Sider (fra-til)1580-7
    Antal sider8
    ISSN0140-6736
    DOI
    StatusUdgivet - 7 maj 2011

    Fingeraftryk

    Dyk ned i forskningsemnerne om 'Risk of triple-class virological failure in children with HIV: a retrospective cohort study'. Sammen danner de et unikt fingeraftryk.

    Citationsformater