Abstract
OBJECTIVE: To evaluate the association between subfertility in men and the subsequent risk of testicular cancer.
DESIGN: Population based case-control study.
SETTING: The Danish population.
PARTICIPANTS: Cases were identified in the Danish Cancer Registry; controls were randomly selected from the Danish population with the computerised Danish Central Population Register. Men were interviewed by telephone; 514 men with cancer and 720 controls participated.
OUTCOME MEASURE: Occurrence of testicular cancer.
RESULTS: A reduced risk of testicular cancer was associated with paternity (relative risk 0.63; 95% confidence interval 0.47 to 0.85). In men who before the diagnosis of testicular cancer had a lower number of children than expected on the basis of their age, the relative risk was 1.98 (1.43 to 2.75). There was no corresponding protective effect associated with a higher number of children than expected. The associations were similar for seminoma and non-seminoma and were not influenced by adjustment for potential confounding factors.
CONCLUSION: These data are consistent with the hypothesis that male subfertility and testicular cancer share important aetiological factors.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | BMJ (Clinical research ed.) |
| Vol/bind | 318 |
| Udgave nummer | 7183 |
| Sider (fra-til) | 559-62 |
| Antal sider | 4 |
| ISSN | 0959-8138 |
| DOI | |
| Status | Udgivet - 27 feb. 1999 |