TY - JOUR
T1 - Risk of stroke the year following a delivery after using assisted reproductive technologies
AU - Magnus, Maria C
AU - Håberg, Siri E
AU - Rönö, Kristiina
AU - Romundstad, Liv Bente
AU - Bergh, Christina
AU - Spangmose, Anne Laerke
AU - Pinborg, Anja
AU - Gissler, Mika
AU - Wennerholm, Ulla-Britt
AU - Opdahl, Signe
N1 - © 2023 The Authors. Paediatric and Perinatal Epidemiology published by John Wiley & Sons Ltd.
PY - 2024/3
Y1 - 2024/3
N2 - BACKGROUND: Studies indicate that individuals who deliver after assisted reproductive technologies (ART) may have an increased risk of cardiovascular disease (CVD). A recent large study from the U.S. showed a higher risk of stroke during the first year after delivery.OBJECTIVES: To compare the risk of stroke during the first year after delivery according to the use of ART in the Nordic countries.METHODS: Registry-based cohort study using nationwide data from Denmark (1994-2014), Finland (1990-2014), Norway (1984-2015) and Sweden (1985-2015). Data on ART conception were available from ART quality registries and/or Medical Birth Registries (MBRs). National data on stroke were available from hospital and cause-of-death registries. The risk of stroke during the first year after delivery was estimated with Cox proportional hazard regression, adjusting for age, calendar year of delivery, multiple births, and country.RESULTS: A total of 2,659,272 primiparous individuals had a registered delivery in the MBRs during the study period, and 91,466 (4%) of these gave birth after ART. We observed no overall increased risk of stroke during the first year after delivery among individuals conceiving after ART (adjusted hazard ratio [HR] 1.10; 95% CI: 0.77, 1.57). Similarly, there was no convincing evidence that the short-term risk of stroke was higher within 1, 2, 3, or 6 months after delivery, with adjusted HRs ranging between 1.23 and 1.33 and confidence intervals including the null value for all time periods. A secondary analysis also including multiparous individuals (n = 3,335,478) at the start of follow-up yielded similar findings.CONCLUSIONS: We found no evidence of an increased short-term risk of stroke among individuals who delivered after using ART.
AB - BACKGROUND: Studies indicate that individuals who deliver after assisted reproductive technologies (ART) may have an increased risk of cardiovascular disease (CVD). A recent large study from the U.S. showed a higher risk of stroke during the first year after delivery.OBJECTIVES: To compare the risk of stroke during the first year after delivery according to the use of ART in the Nordic countries.METHODS: Registry-based cohort study using nationwide data from Denmark (1994-2014), Finland (1990-2014), Norway (1984-2015) and Sweden (1985-2015). Data on ART conception were available from ART quality registries and/or Medical Birth Registries (MBRs). National data on stroke were available from hospital and cause-of-death registries. The risk of stroke during the first year after delivery was estimated with Cox proportional hazard regression, adjusting for age, calendar year of delivery, multiple births, and country.RESULTS: A total of 2,659,272 primiparous individuals had a registered delivery in the MBRs during the study period, and 91,466 (4%) of these gave birth after ART. We observed no overall increased risk of stroke during the first year after delivery among individuals conceiving after ART (adjusted hazard ratio [HR] 1.10; 95% CI: 0.77, 1.57). Similarly, there was no convincing evidence that the short-term risk of stroke was higher within 1, 2, 3, or 6 months after delivery, with adjusted HRs ranging between 1.23 and 1.33 and confidence intervals including the null value for all time periods. A secondary analysis also including multiparous individuals (n = 3,335,478) at the start of follow-up yielded similar findings.CONCLUSIONS: We found no evidence of an increased short-term risk of stroke among individuals who delivered after using ART.
KW - Cohort Studies
KW - Female
KW - Humans
KW - Norway
KW - Registries
KW - Reproductive Techniques, Assisted
KW - Scandinavian and Nordic Countries
KW - Stroke/etiology
KW - asisted reproductive technologies
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=85181205206&partnerID=8YFLogxK
U2 - 10.1111/ppe.13037
DO - 10.1111/ppe.13037
M3 - Journal article
C2 - 38156709
SN - 1365-3016
VL - 38
SP - 197
EP - 201
JO - Paediatric and perinatal epidemiology
JF - Paediatric and perinatal epidemiology
IS - 3
ER -