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Risk of skin cancer in HIV-infected patients: a Danish nationwide cohort study

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@article{d8ce0166238743dca69119530fe89870,
title = "Risk of skin cancer in HIV-infected patients: a Danish nationwide cohort study",
abstract = "BACKGROUND: The risk of skin cancer in HIV-infected patients has not been extensively studied.OBJECTIVE: To determine the risk of skin cancer in HIV-infected patients and compare it with the risk in the background population.METHODS: In a matched, nationwide population-based cohort study we compared the risk of skin cancer in 4280 HIV-infected patients from the Danish HIV cohort study with a background population cohort, according to the level of immunosuppression and route of transmission. Primary outcomes were time to first basal cell carcinoma (BCC), squamous cell carcinoma (SCC), or malignant melanoma (MM).RESULTS: HIV-infected patients had an increased risk of BCC and SCC with IRRs of 1.79 (95{\%} CI 1.43 - 2.22) and 5.40 (95{\%} CI 3.07 - 9.52), respectively, compared with the background population. We observed no increased risk of MM. Low nadir CD4 cell count was associated with an increased risk of SCC. The increased risk of BCC among HIV-infected patients was restricted to men who had sex with men.LIMITATIONS: Observational design. Small number of patients with melanoma.CONCLUSION: HIV-infected patients have an increased risk of BCC and SCC. Low nadir, but not current, CD4 cell count as a marker of immunosuppression was associated with an increased risk of SCC.",
keywords = "Journal Article",
author = "Omland, {Silje Haukali} and Ahlstr{\"o}m, {Magnus Glinvad} and Jan Gerstoft and Gitte Pedersen and Rajesh Mohey and Court Pedersen and Gitte Kronborg and Larsen, {Carsten Schade} and Birgit Kvinesdal and Robert Gniadecki and Niels Obel and Omland, {Lars Haukali}",
note = "Copyright {\circledC} 2018. Published by Elsevier Inc.",
year = "2018",
doi = "10.1016/j.jaad.2018.03.024",
language = "English",
volume = "79",
pages = "689--695",
journal = "American Academy of Dermatology. Journal",
issn = "0190-9622",
publisher = "Mosby, Inc",
number = "4",

}

RIS

TY - JOUR

T1 - Risk of skin cancer in HIV-infected patients

T2 - a Danish nationwide cohort study

AU - Omland, Silje Haukali

AU - Ahlström, Magnus Glinvad

AU - Gerstoft, Jan

AU - Pedersen, Gitte

AU - Mohey, Rajesh

AU - Pedersen, Court

AU - Kronborg, Gitte

AU - Larsen, Carsten Schade

AU - Kvinesdal, Birgit

AU - Gniadecki, Robert

AU - Obel, Niels

AU - Omland, Lars Haukali

N1 - Copyright © 2018. Published by Elsevier Inc.

PY - 2018

Y1 - 2018

N2 - BACKGROUND: The risk of skin cancer in HIV-infected patients has not been extensively studied.OBJECTIVE: To determine the risk of skin cancer in HIV-infected patients and compare it with the risk in the background population.METHODS: In a matched, nationwide population-based cohort study we compared the risk of skin cancer in 4280 HIV-infected patients from the Danish HIV cohort study with a background population cohort, according to the level of immunosuppression and route of transmission. Primary outcomes were time to first basal cell carcinoma (BCC), squamous cell carcinoma (SCC), or malignant melanoma (MM).RESULTS: HIV-infected patients had an increased risk of BCC and SCC with IRRs of 1.79 (95% CI 1.43 - 2.22) and 5.40 (95% CI 3.07 - 9.52), respectively, compared with the background population. We observed no increased risk of MM. Low nadir CD4 cell count was associated with an increased risk of SCC. The increased risk of BCC among HIV-infected patients was restricted to men who had sex with men.LIMITATIONS: Observational design. Small number of patients with melanoma.CONCLUSION: HIV-infected patients have an increased risk of BCC and SCC. Low nadir, but not current, CD4 cell count as a marker of immunosuppression was associated with an increased risk of SCC.

AB - BACKGROUND: The risk of skin cancer in HIV-infected patients has not been extensively studied.OBJECTIVE: To determine the risk of skin cancer in HIV-infected patients and compare it with the risk in the background population.METHODS: In a matched, nationwide population-based cohort study we compared the risk of skin cancer in 4280 HIV-infected patients from the Danish HIV cohort study with a background population cohort, according to the level of immunosuppression and route of transmission. Primary outcomes were time to first basal cell carcinoma (BCC), squamous cell carcinoma (SCC), or malignant melanoma (MM).RESULTS: HIV-infected patients had an increased risk of BCC and SCC with IRRs of 1.79 (95% CI 1.43 - 2.22) and 5.40 (95% CI 3.07 - 9.52), respectively, compared with the background population. We observed no increased risk of MM. Low nadir CD4 cell count was associated with an increased risk of SCC. The increased risk of BCC among HIV-infected patients was restricted to men who had sex with men.LIMITATIONS: Observational design. Small number of patients with melanoma.CONCLUSION: HIV-infected patients have an increased risk of BCC and SCC. Low nadir, but not current, CD4 cell count as a marker of immunosuppression was associated with an increased risk of SCC.

KW - Journal Article

U2 - 10.1016/j.jaad.2018.03.024

DO - 10.1016/j.jaad.2018.03.024

M3 - Journal article

VL - 79

SP - 689

EP - 695

JO - American Academy of Dermatology. Journal

JF - American Academy of Dermatology. Journal

SN - 0190-9622

IS - 4

ER -

ID: 53548301