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Risk of skin cancer in HIV-infected patients: a Danish nationwide cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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BACKGROUND: The risk of skin cancer in HIV-infected patients has not been extensively studied.

OBJECTIVE: To determine the risk of skin cancer in HIV-infected patients and compare it with the risk in the background population.

METHODS: In a matched, nationwide population-based cohort study we compared the risk of skin cancer in 4280 HIV-infected patients from the Danish HIV cohort study with a background population cohort, according to the level of immunosuppression and route of transmission. Primary outcomes were time to first basal cell carcinoma (BCC), squamous cell carcinoma (SCC), or malignant melanoma (MM).

RESULTS: HIV-infected patients had an increased risk of BCC and SCC with IRRs of 1.79 (95% CI 1.43 - 2.22) and 5.40 (95% CI 3.07 - 9.52), respectively, compared with the background population. We observed no increased risk of MM. Low nadir CD4 cell count was associated with an increased risk of SCC. The increased risk of BCC among HIV-infected patients was restricted to men who had sex with men.

LIMITATIONS: Observational design. Small number of patients with melanoma.

CONCLUSION: HIV-infected patients have an increased risk of BCC and SCC. Low nadir, but not current, CD4 cell count as a marker of immunosuppression was associated with an increased risk of SCC.

OriginalsprogEngelsk
TidsskriftJournal of the American Academy of Dermatology
Vol/bind79
Udgave nummer4
Sider (fra-til)689-695
ISSN0190-9622
DOI
StatusUdgivet - 2018

ID: 53548301