TY - JOUR
T1 - Risk of skin cancer in HIV-infected patients
T2 - a Danish nationwide cohort study
AU - Omland, Silje Haukali
AU - Ahlström, Magnus Glinvad
AU - Gerstoft, Jan
AU - Pedersen, Gitte
AU - Mohey, Rajesh
AU - Pedersen, Court
AU - Kronborg, Gitte
AU - Larsen, Carsten Schade
AU - Kvinesdal, Birgit
AU - Gniadecki, Robert
AU - Obel, Niels
AU - Omland, Lars Haukali
N1 - Copyright © 2018. Published by Elsevier Inc.
PY - 2018
Y1 - 2018
N2 - BACKGROUND: The risk of skin cancer in HIV-infected patients has not been extensively studied.OBJECTIVE: To determine the risk of skin cancer in HIV-infected patients and compare it with the risk in the background population.METHODS: In a matched, nationwide population-based cohort study we compared the risk of skin cancer in 4280 HIV-infected patients from the Danish HIV cohort study with a background population cohort, according to the level of immunosuppression and route of transmission. Primary outcomes were time to first basal cell carcinoma (BCC), squamous cell carcinoma (SCC), or malignant melanoma (MM).RESULTS: HIV-infected patients had an increased risk of BCC and SCC with IRRs of 1.79 (95% CI 1.43 - 2.22) and 5.40 (95% CI 3.07 - 9.52), respectively, compared with the background population. We observed no increased risk of MM. Low nadir CD4 cell count was associated with an increased risk of SCC. The increased risk of BCC among HIV-infected patients was restricted to men who had sex with men.LIMITATIONS: Observational design. Small number of patients with melanoma.CONCLUSION: HIV-infected patients have an increased risk of BCC and SCC. Low nadir, but not current, CD4 cell count as a marker of immunosuppression was associated with an increased risk of SCC.
AB - BACKGROUND: The risk of skin cancer in HIV-infected patients has not been extensively studied.OBJECTIVE: To determine the risk of skin cancer in HIV-infected patients and compare it with the risk in the background population.METHODS: In a matched, nationwide population-based cohort study we compared the risk of skin cancer in 4280 HIV-infected patients from the Danish HIV cohort study with a background population cohort, according to the level of immunosuppression and route of transmission. Primary outcomes were time to first basal cell carcinoma (BCC), squamous cell carcinoma (SCC), or malignant melanoma (MM).RESULTS: HIV-infected patients had an increased risk of BCC and SCC with IRRs of 1.79 (95% CI 1.43 - 2.22) and 5.40 (95% CI 3.07 - 9.52), respectively, compared with the background population. We observed no increased risk of MM. Low nadir CD4 cell count was associated with an increased risk of SCC. The increased risk of BCC among HIV-infected patients was restricted to men who had sex with men.LIMITATIONS: Observational design. Small number of patients with melanoma.CONCLUSION: HIV-infected patients have an increased risk of BCC and SCC. Low nadir, but not current, CD4 cell count as a marker of immunosuppression was associated with an increased risk of SCC.
KW - Journal Article
U2 - 10.1016/j.jaad.2018.03.024
DO - 10.1016/j.jaad.2018.03.024
M3 - Journal article
C2 - 29588249
SN - 0190-9622
VL - 79
SP - 689
EP - 695
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 4
ER -