Risk of New Primary Cancer in Patients with Posterior Uveal Melanoma: A National Cohort Study

Mette Bagger*, Vanna Albieri, Tine Gadegaard Hindso, Karin Wadt, Steffen Heegaard, Klaus Kaae Andersen, Jens Folke Kiilgaard

*Corresponding author af dette arbejde
5 Citationer (Scopus)

Abstract

BACKGROUND: Studies on the risk of new primary cancer in patients with posterior uveal melanoma (UM) have produced conflicting results, and the role of socioeconomic status (SES) is unknown. The purpose of this population-based matched cohort study was to determine the risk of new primary cancer following the diagnosis of posterior UM.

METHODS: 2179 patients with posterior UM 1968-2016 and 22,717 matched controls without cancer were included. Incidence and time-dependent hazard ratio (HR) of new primary cancer were described, and the effect of SES was emphasized in a sub-cohort.

RESULTS: The incidence of new primary cancer was increased in patients with posterior UM, rate ratio (RR) 1.21 (95% CI: 1.08; 1.35), but the specific cancer types did not differ compared to the controls. The rate of new primary cancer following the diagnosis of posterior UM was significantly increased 2-5 years (HR 1.49 (95% CI: 1.23; 1.80)) and 11-15 years (HR: 1.49 (95% CI: 1.12; 1.99)), and adjusting for SES did not change the rate (HR 1.35 (95% CI:1.20; 1.55)).

CONCLUSIONS: Patients with posterior UM have an increased risk of new primary cancer independent of SES. No difference in incidence of specific cancer type was observed compared to the control group.

OriginalsprogEngelsk
Artikelnummer284
TidsskriftCancers
Vol/bind14
Udgave nummer2
Sider (fra-til)1-11
Antal sider11
ISSN2072-6694
DOI
StatusUdgivet - 7 jan. 2022

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