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Risk of neurological disorders in patients with European Lyme neuroborreliosis. A nationwide population-based cohort study

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@article{e1bbdac4babd4cdeb5bc994dea204667,
title = "Risk of neurological disorders in patients with European Lyme neuroborreliosis. A nationwide population-based cohort study",
abstract = "BACKGROUND: Lyme neuroborreliosis (LNB), caused by the tick-borne spirochetes of the Borrelia burgdorferi sensu lato species complex, has been suggested to be associated with a range of neurological disorders. In a nationwide, population-based cohort study, we examined the associations between LNB and dementia, Alzheimer's disease, Parkinson's disease, motor neuron disease, epilepsy, and Guillain-Barr{\'e} syndrome.METHODS: We used national registers to identify all Danish residents diagnosed during 1986-2016 with LNB (n = 2067), created a gender- and age-matched comparison cohort from the general population (n = 20 670), and calculated risk estimates and hazard ratios.RESULTS: We observed no long-term increased risks of dementia, Alzheimer's disease, Parkinson's disease, motor neuron diseases, or epilepsy. However, within the first year, 8 (0.4{\%}) of the LNB patients developed epilepsy, compared with 20 (0.1{\%}) of the comparison cohort (difference, 0.3{\%}; 95{\%} confidence interval, .02-.6{\%}). In the LNB group, 11 (0.5{\%}) patients were diagnosed with Guillain-Barr{\'e} syndrome within the first year after LNB diagnosis, compared with 0 (0.0{\%}) in the comparison cohort. After the first year, the risk of Guillain-Barr{\'e} was not increased.CONCLUSIONS: LNB patients did not have increased long-term risks of dementia, Alzheimer's disease, Parkinson's disease, motor neuron diseases, epilepsy, or Guillain-Barr{\'e}. Although the absolute risk is low, LNB patients might have an increased short-term risk of epilepsy and Guillain-Barr{\'e} syndrome.",
author = "Rasmus Haahr and Tetens, {Malte M} and Dessau, {Ram B} and Krogfelt, {Karen A} and Jacob Bodilsen and Andersen, {Nanna S} and M{\o}ller, {Jens K} and Casper Roed and Christiansen, {Claus B} and Svend Ellermann-Eriksen and Bangsborg, {Jette M} and Klaus Hansen and Benfield, {Thomas L} and {{\O}stergaard Andersen}, Christian and Niels Obel and Anne-Mette Lebech and Omland, {Lars H}",
note = "{\circledC} The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2020",
month = "9",
day = "12",
doi = "10.1093/cid/ciz997",
language = "English",
volume = "71",
pages = "1511--1516",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "University of Chicago Press",
number = "6",

}

RIS

TY - JOUR

T1 - Risk of neurological disorders in patients with European Lyme neuroborreliosis. A nationwide population-based cohort study

AU - Haahr, Rasmus

AU - Tetens, Malte M

AU - Dessau, Ram B

AU - Krogfelt, Karen A

AU - Bodilsen, Jacob

AU - Andersen, Nanna S

AU - Møller, Jens K

AU - Roed, Casper

AU - Christiansen, Claus B

AU - Ellermann-Eriksen, Svend

AU - Bangsborg, Jette M

AU - Hansen, Klaus

AU - Benfield, Thomas L

AU - Østergaard Andersen, Christian

AU - Obel, Niels

AU - Lebech, Anne-Mette

AU - Omland, Lars H

N1 - © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2020/9/12

Y1 - 2020/9/12

N2 - BACKGROUND: Lyme neuroborreliosis (LNB), caused by the tick-borne spirochetes of the Borrelia burgdorferi sensu lato species complex, has been suggested to be associated with a range of neurological disorders. In a nationwide, population-based cohort study, we examined the associations between LNB and dementia, Alzheimer's disease, Parkinson's disease, motor neuron disease, epilepsy, and Guillain-Barré syndrome.METHODS: We used national registers to identify all Danish residents diagnosed during 1986-2016 with LNB (n = 2067), created a gender- and age-matched comparison cohort from the general population (n = 20 670), and calculated risk estimates and hazard ratios.RESULTS: We observed no long-term increased risks of dementia, Alzheimer's disease, Parkinson's disease, motor neuron diseases, or epilepsy. However, within the first year, 8 (0.4%) of the LNB patients developed epilepsy, compared with 20 (0.1%) of the comparison cohort (difference, 0.3%; 95% confidence interval, .02-.6%). In the LNB group, 11 (0.5%) patients were diagnosed with Guillain-Barré syndrome within the first year after LNB diagnosis, compared with 0 (0.0%) in the comparison cohort. After the first year, the risk of Guillain-Barré was not increased.CONCLUSIONS: LNB patients did not have increased long-term risks of dementia, Alzheimer's disease, Parkinson's disease, motor neuron diseases, epilepsy, or Guillain-Barré. Although the absolute risk is low, LNB patients might have an increased short-term risk of epilepsy and Guillain-Barré syndrome.

AB - BACKGROUND: Lyme neuroborreliosis (LNB), caused by the tick-borne spirochetes of the Borrelia burgdorferi sensu lato species complex, has been suggested to be associated with a range of neurological disorders. In a nationwide, population-based cohort study, we examined the associations between LNB and dementia, Alzheimer's disease, Parkinson's disease, motor neuron disease, epilepsy, and Guillain-Barré syndrome.METHODS: We used national registers to identify all Danish residents diagnosed during 1986-2016 with LNB (n = 2067), created a gender- and age-matched comparison cohort from the general population (n = 20 670), and calculated risk estimates and hazard ratios.RESULTS: We observed no long-term increased risks of dementia, Alzheimer's disease, Parkinson's disease, motor neuron diseases, or epilepsy. However, within the first year, 8 (0.4%) of the LNB patients developed epilepsy, compared with 20 (0.1%) of the comparison cohort (difference, 0.3%; 95% confidence interval, .02-.6%). In the LNB group, 11 (0.5%) patients were diagnosed with Guillain-Barré syndrome within the first year after LNB diagnosis, compared with 0 (0.0%) in the comparison cohort. After the first year, the risk of Guillain-Barré was not increased.CONCLUSIONS: LNB patients did not have increased long-term risks of dementia, Alzheimer's disease, Parkinson's disease, motor neuron diseases, epilepsy, or Guillain-Barré. Although the absolute risk is low, LNB patients might have an increased short-term risk of epilepsy and Guillain-Barré syndrome.

U2 - 10.1093/cid/ciz997

DO - 10.1093/cid/ciz997

M3 - Journal article

VL - 71

SP - 1511

EP - 1516

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 6

ER -

ID: 58139318