Risk of intensive care unit admission and mortality in patients hospitalized due to influenza A or B and SARS‑CoV‑2 variants Omicron or Delta

Omid Rezahosseini; Casper Roed; Adin Sejdic; Mads Frederik Eiberg; Lene Nielsen; Jonas Boel; Caroline Klint Johannesen; Maarten van Wijhe; Kristina Træholt Franck; Sisse Rye Ostrowski; Birgitte Lindegaard; Thea K. Fischer; Troels Bygum Knudsen; Jon Gitz Holler; Zitta Barrella Harboe; Betina Lindgaard-Jensen; Christian Søborg; Thyge Lynghøj Nielsen; Peter Haahr Bernhard; Emilie Marie Juelstorp Pedersen; Gertrud Baunbæk Egelund; Inger Hee Mabuza Mathiesen; Naja Zenius Jespersen; Pelle Trier Petersen; Hans Eric Sebastian Seitz-Rasmussen; Barbara Bonnesen Bertelsen; Morten Bestle; Henrik Andersen; Thomas Ulrik Skram; Sarah Altaraihi; Pradeesh Sivapalan; Jens Ulrik Stæhr Jensen; Kristian Bagge; Kristina Melbardis Jørgensen; Magnus Glindvad Ahlström; Sofie Rytter; Nina le Dous; Pernille Ravn; Nanna Reiter; Daria Podlekareva; Jesper Andreas Knudsen; Lars Erik Kristensen; Cæcilie Leding; Thomas Benfield; Ole Kirk; Sigurdur Thor Sigurdsson; Martin Schou Pedersen; the COVID-19 Omicron Delta study group collaborators

doi:10.1002/iid3.1269

Risk of intensive care unit admission and mortality in patients hospitalized due to influenza A or B and SARS‑CoV‑2 variants Omicron or Delta

Omid Rezahosseini, Casper Roed, Adin Sejdic, Mads Frederik Eiberg, Lene Nielsen, Jonas Boel, Caroline Klint Johannesen, Maarten van Wijhe, Kristina Træholt Franck, Sisse Rye Ostrowski, Birgitte Lindegaard, Thea K. Fischer, Troels Bygum Knudsen, Jon Gitz Holler^*, Zitta Barrella Harboe^*, Betina Lindgaard-Jensen (Medlem af forfattergruppering), Christian Søborg (Medlem af forfattergruppering), Thyge Lynghøj Nielsen (Medlem af forfattergruppering), Peter Haahr Bernhard (Medlem af forfattergruppering), Emilie Marie Juelstorp Pedersen (Medlem af forfattergruppering)Gertrud Baunbæk Egelund (Medlem af forfattergruppering), Inger Hee Mabuza Mathiesen (Medlem af forfattergruppering), Naja Zenius Jespersen (Medlem af forfattergruppering), Pelle Trier Petersen (Medlem af forfattergruppering), Hans Eric Sebastian Seitz-Rasmussen (Medlem af forfattergruppering), Barbara Bonnesen Bertelsen (Medlem af forfattergruppering), Morten Bestle (Medlem af forfattergruppering), Henrik Andersen (Medlem af forfattergruppering), Thomas Ulrik Skram (Medlem af forfattergruppering), Sarah Altaraihi (Medlem af forfattergruppering), Pradeesh Sivapalan (Medlem af forfattergruppering), Jens Ulrik Stæhr Jensen (Medlem af forfattergruppering), Kristian Bagge, Kristina Melbardis Jørgensen, Magnus Glindvad Ahlström (Medlem af forfattergruppering), Sofie Rytter (Medlem af forfattergruppering), Nina le Dous (Medlem af forfattergruppering), Pernille Ravn (Medlem af forfattergruppering), Nanna Reiter (Medlem af forfattergruppering), Daria Podlekareva (Medlem af forfattergruppering), Jesper Andreas Knudsen (Medlem af forfattergruppering), Lars Erik Kristensen (Medlem af forfattergruppering), Cæcilie Leding (Medlem af forfattergruppering), Thomas Benfield (Medlem af forfattergruppering), Ole Kirk (Medlem af forfattergruppering), Sigurdur Thor Sigurdsson (Medlem af forfattergruppering), Martin Schou Pedersen (Medlem af forfattergruppering), the COVID-19 Omicron Delta study group collaborators

^*Corresponding author af dette arbejde

2 Citationer (Scopus)

Abstract

BACKGROUND: Respiratory viral infections have significant global health impacts. We compared 30-day intensive care unit (ICU) admission and all-cause mortality risks in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta and Omicron variants versus influenza A and B (A/B).

METHODS: Data from two retrospective inpatient cohorts in Capital Region of Denmark were analyzed. Cohorts included hospitalized influenza A/B patients (2017-2018) and SARS-CoV-2 Delta/Omicron patients (2021-2022), aged ≥18 years, admitted within 14 days of a positive real-time polymerase chain reaction test result. Cumulative ICU admission and mortality rates were estimated using the Aalen-Johansen estimator. Cox regression models calculated hazard ratios (HRs) for ICU admission and mortality.

RESULTS: The study encompassed 1459 inpatients (Delta: 49%; Omicron: 26%; influenza A: 6.4%; and influenza B: 18%). Cumulative incidence of ICU admission was 11%, 4.0%, 7.5%, and 4.1%, for Delta, Omicron, influenza A, and B, respectively. For ICU admission, adjusted HRs (aHRs) were 3.1 (p < .001) and 1.5 (p = .34) for Delta and Omicron versus influenza B, and 1.5 (p = .36) and 0.71 (p = .48) versus influenza A. For mortality, aHRs were 3.8 (p < .001) and 3.4 (p < .001) for Delta and Omicron versus influenza B, and 2.1 (p = .04) and 1.9 (p = .11) versus influenza A.

CONCLUSION: Delta but not Omicron inpatients had an increased risk for ICU admission compared to influenza B; however, both variants were associated with higher risks of mortality than influenza B. Only Delta inpatients had a higher risk of mortality than influenza A inpatients.

Originalsprog	Engelsk
Artikelnummer	e1269
Tidsskrift	Immunity, Inflammation and Disease
Vol/bind	12
Udgave nummer	7
ISSN	2050-4527
DOI	https://doi.org/10.1002/iid3.1269
Status	Udgivet - jul. 2024

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10.1002/iid3.1269

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Rezahosseini, O., Roed, C., Sejdic, A., Eiberg, M. F., Nielsen, L., Boel, J., Johannesen, C. K., van Wijhe, M., Franck, K. T., Ostrowski, S. R., Lindegaard, B., Fischer, T. K., Knudsen, T. B., Holler, J. G., Harboe, Z. B., Lindgaard-Jensen, B., Søborg, C., Nielsen, T. L., Bernhard, P. H., ... the COVID-19 Omicron Delta study group collaborators (2024). Risk of intensive care unit admission and mortality in patients hospitalized due to influenza A or B and SARS‑CoV‑2 variants Omicron or Delta. Immunity, Inflammation and Disease, 12(7), Artikel e1269. https://doi.org/10.1002/iid3.1269

Rezahosseini, O , Roed, C , Sejdic, A , Eiberg, MF , Nielsen, L , Boel, J , Johannesen, CK, van Wijhe, M, Franck, KT, Ostrowski, SR , Lindegaard, B , Fischer, TK , Knudsen, TB , Holler, JG , Harboe, ZB , Lindgaard-Jensen, B , Søborg, C , Nielsen, TL , Bernhard, PH , Pedersen, EMJ , Egelund, GB, Mathiesen, IHM, Jespersen, NZ , Petersen, PT , Seitz-Rasmussen, HES , Bertelsen, BB , Bestle, M, Andersen, H, Skram, TU, Altaraihi, S, Sivapalan, P , Jensen, JUS , Bagge, K , Jørgensen, KM , Ahlström, MG, Rytter, S, le Dous, N, Ravn, P , Reiter, N , Podlekareva, D , Knudsen, JA , Kristensen, LE , Leding, C , Benfield, T , Kirk, O , Sigurdsson, ST , Pedersen, MS & the COVID-19 Omicron Delta study group collaborators 2024, 'Risk of intensive care unit admission and mortality in patients hospitalized due to influenza A or B and SARS‑CoV‑2 variants Omicron or Delta', Immunity, Inflammation and Disease, bind 12, nr. 7, e1269. https://doi.org/10.1002/iid3.1269

@article{11f963a42e2c4bef9a16b2dade969552,

title = "Risk of intensive care unit admission and mortality in patients hospitalized due to influenza A or B and SARS‑CoV‑2 variants Omicron or Delta",

abstract = "BACKGROUND: Respiratory viral infections have significant global health impacts. We compared 30-day intensive care unit (ICU) admission and all-cause mortality risks in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta and Omicron variants versus influenza A and B (A/B).METHODS: Data from two retrospective inpatient cohorts in Capital Region of Denmark were analyzed. Cohorts included hospitalized influenza A/B patients (2017-2018) and SARS-CoV-2 Delta/Omicron patients (2021-2022), aged ≥18 years, admitted within 14 days of a positive real-time polymerase chain reaction test result. Cumulative ICU admission and mortality rates were estimated using the Aalen-Johansen estimator. Cox regression models calculated hazard ratios (HRs) for ICU admission and mortality.RESULTS: The study encompassed 1459 inpatients (Delta: 49%; Omicron: 26%; influenza A: 6.4%; and influenza B: 18%). Cumulative incidence of ICU admission was 11%, 4.0%, 7.5%, and 4.1%, for Delta, Omicron, influenza A, and B, respectively. For ICU admission, adjusted HRs (aHRs) were 3.1 (p < .001) and 1.5 (p = .34) for Delta and Omicron versus influenza B, and 1.5 (p = .36) and 0.71 (p = .48) versus influenza A. For mortality, aHRs were 3.8 (p < .001) and 3.4 (p < .001) for Delta and Omicron versus influenza B, and 2.1 (p = .04) and 1.9 (p = .11) versus influenza A.CONCLUSION: Delta but not Omicron inpatients had an increased risk for ICU admission compared to influenza B; however, both variants were associated with higher risks of mortality than influenza B. Only Delta inpatients had a higher risk of mortality than influenza A inpatients.",

keywords = "influenza A, influenza B, intensive care units, mortality, SARS-CoV-2 Delta variants, SARS-CoV-2 Omicron variant",

author = "Omid Rezahosseini and Casper Roed and Adin Sejdic and Eiberg, {Mads Frederik} and Lene Nielsen and Jonas Boel and Johannesen, {Caroline Klint} and {van Wijhe}, Maarten and Franck, {Kristina Tr{\ae}holt} and Ostrowski, {Sisse Rye} and Birgitte Lindegaard and Fischer, {Thea K.} and Knudsen, {Troels Bygum} and Holler, {Jon Gitz} and Harboe, {Zitta Barrella} and Betina Lindgaard-Jensen and Christian S{\o}borg and Nielsen, {Thyge Lyngh{\o}j} and Bernhard, {Peter Haahr} and Pedersen, {Emilie Marie Juelstorp} and Egelund, {Gertrud Baunb{\ae}k} and Mathiesen, {Inger Hee Mabuza} and Jespersen, {Naja Zenius} and Petersen, {Pelle Trier} and Seitz-Rasmussen, {Hans Eric Sebastian} and Bertelsen, {Barbara Bonnesen} and Morten Bestle and Henrik Andersen and Skram, {Thomas Ulrik} and Sarah Altaraihi and Pradeesh Sivapalan and Jensen, {Jens Ulrik St{\ae}hr} and Kristian Bagge and J{\o}rgensen, {Kristina Melbardis} and Ahlstr{\"o}m, {Magnus Glindvad} and Sofie Rytter and {le Dous}, Nina and Pernille Ravn and Nanna Reiter and Daria Podlekareva and Knudsen, {Jesper Andreas} and Kristensen, {Lars Erik} and C{\ae}cilie Leding and Thomas Benfield and Ole Kirk and Sigurdsson, {Sigurdur Thor} and Pedersen, {Martin Schou} and {the COVID-19 Omicron Delta study group collaborators}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.",

year = "2024",

month = jul,

doi = "10.1002/iid3.1269",

language = "English",

volume = "12",

journal = "Immunity, Inflammation and Disease",

issn = "2050-4527",

publisher = "JohnWiley & Sons Ltd",

number = "7",

}

TY - JOUR

T1 - Risk of intensive care unit admission and mortality in patients hospitalized due to influenza A or B and SARS‑CoV‑2 variants Omicron or Delta

AU - Rezahosseini, Omid

AU - Roed, Casper

AU - Sejdic, Adin

AU - Eiberg, Mads Frederik

AU - Nielsen, Lene

AU - Boel, Jonas

AU - Johannesen, Caroline Klint

AU - van Wijhe, Maarten

AU - Franck, Kristina Træholt

AU - Ostrowski, Sisse Rye

AU - Lindegaard, Birgitte

AU - Fischer, Thea K.

AU - Knudsen, Troels Bygum

AU - Holler, Jon Gitz

AU - Harboe, Zitta Barrella

AU - Bagge, Kristian

AU - Jørgensen, Kristina Melbardis

AU - the COVID-19 Omicron Delta study group collaborators

A2 - Lindgaard-Jensen, Betina

A2 - Søborg, Christian

A2 - Nielsen, Thyge Lynghøj

A2 - Bernhard, Peter Haahr

A2 - Pedersen, Emilie Marie Juelstorp

A2 - Egelund, Gertrud Baunbæk

A2 - Mathiesen, Inger Hee Mabuza

A2 - Jespersen, Naja Zenius

A2 - Petersen, Pelle Trier

A2 - Seitz-Rasmussen, Hans Eric Sebastian

A2 - Bertelsen, Barbara Bonnesen

A2 - Bestle, Morten

A2 - Andersen, Henrik

A2 - Skram, Thomas Ulrik

A2 - Altaraihi, Sarah

A2 - Sivapalan, Pradeesh

A2 - Jensen, Jens Ulrik Stæhr

A2 - Ahlström, Magnus Glindvad

A2 - Rytter, Sofie

A2 - le Dous, Nina

A2 - Ravn, Pernille

A2 - Reiter, Nanna

A2 - Podlekareva, Daria

A2 - Knudsen, Jesper Andreas

A2 - Kristensen, Lars Erik

A2 - Leding, Cæcilie

A2 - Benfield, Thomas

A2 - Kirk, Ole

A2 - Sigurdsson, Sigurdur Thor

A2 - Pedersen, Martin Schou

PY - 2024/7

Y1 - 2024/7

N2 - BACKGROUND: Respiratory viral infections have significant global health impacts. We compared 30-day intensive care unit (ICU) admission and all-cause mortality risks in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta and Omicron variants versus influenza A and B (A/B).METHODS: Data from two retrospective inpatient cohorts in Capital Region of Denmark were analyzed. Cohorts included hospitalized influenza A/B patients (2017-2018) and SARS-CoV-2 Delta/Omicron patients (2021-2022), aged ≥18 years, admitted within 14 days of a positive real-time polymerase chain reaction test result. Cumulative ICU admission and mortality rates were estimated using the Aalen-Johansen estimator. Cox regression models calculated hazard ratios (HRs) for ICU admission and mortality.RESULTS: The study encompassed 1459 inpatients (Delta: 49%; Omicron: 26%; influenza A: 6.4%; and influenza B: 18%). Cumulative incidence of ICU admission was 11%, 4.0%, 7.5%, and 4.1%, for Delta, Omicron, influenza A, and B, respectively. For ICU admission, adjusted HRs (aHRs) were 3.1 (p < .001) and 1.5 (p = .34) for Delta and Omicron versus influenza B, and 1.5 (p = .36) and 0.71 (p = .48) versus influenza A. For mortality, aHRs were 3.8 (p < .001) and 3.4 (p < .001) for Delta and Omicron versus influenza B, and 2.1 (p = .04) and 1.9 (p = .11) versus influenza A.CONCLUSION: Delta but not Omicron inpatients had an increased risk for ICU admission compared to influenza B; however, both variants were associated with higher risks of mortality than influenza B. Only Delta inpatients had a higher risk of mortality than influenza A inpatients.

AB - BACKGROUND: Respiratory viral infections have significant global health impacts. We compared 30-day intensive care unit (ICU) admission and all-cause mortality risks in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta and Omicron variants versus influenza A and B (A/B).METHODS: Data from two retrospective inpatient cohorts in Capital Region of Denmark were analyzed. Cohorts included hospitalized influenza A/B patients (2017-2018) and SARS-CoV-2 Delta/Omicron patients (2021-2022), aged ≥18 years, admitted within 14 days of a positive real-time polymerase chain reaction test result. Cumulative ICU admission and mortality rates were estimated using the Aalen-Johansen estimator. Cox regression models calculated hazard ratios (HRs) for ICU admission and mortality.RESULTS: The study encompassed 1459 inpatients (Delta: 49%; Omicron: 26%; influenza A: 6.4%; and influenza B: 18%). Cumulative incidence of ICU admission was 11%, 4.0%, 7.5%, and 4.1%, for Delta, Omicron, influenza A, and B, respectively. For ICU admission, adjusted HRs (aHRs) were 3.1 (p < .001) and 1.5 (p = .34) for Delta and Omicron versus influenza B, and 1.5 (p = .36) and 0.71 (p = .48) versus influenza A. For mortality, aHRs were 3.8 (p < .001) and 3.4 (p < .001) for Delta and Omicron versus influenza B, and 2.1 (p = .04) and 1.9 (p = .11) versus influenza A.CONCLUSION: Delta but not Omicron inpatients had an increased risk for ICU admission compared to influenza B; however, both variants were associated with higher risks of mortality than influenza B. Only Delta inpatients had a higher risk of mortality than influenza A inpatients.

KW - influenza A

KW - influenza B

KW - intensive care units

KW - mortality

KW - SARS-CoV-2 Delta variants

KW - SARS-CoV-2 Omicron variant

UR - http://www.scopus.com/inward/record.url?scp=85197802004&partnerID=8YFLogxK

U2 - 10.1002/iid3.1269

DO - 10.1002/iid3.1269

M3 - Journal article

C2 - 40499155

AN - SCOPUS:85197802004

SN - 2050-4527

VL - 12

JO - Immunity, Inflammation and Disease

JF - Immunity, Inflammation and Disease

IS - 7

M1 - e1269

ER -

Risk of intensive care unit admission and mortality in patients hospitalized due to influenza A or B and SARS‑CoV‑2 variants Omicron or Delta

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