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Risk of cancer in bipolar disorder and the potential role of lithium: International collaborative systematic review and meta-analyses

Publikation: Bidrag til tidsskriftReviewpeer review

Harvard

Anmella, G, Fico, G, Lotfaliany, M, Hidalgo-Mazzei, D, Soto-Angona, Ó, Giménez-Palomo, A, Amoretti, S, Murru, A, Radua, J, Solanes, A, Pacchiarotti, I, Verdolini, N, Cowdery, S, Dodd, S, Williams, LJ, Mohebbi, M, Carvalho, AF, Kessing, LV, Vieta, E & Berk, M 2021, 'Risk of cancer in bipolar disorder and the potential role of lithium: International collaborative systematic review and meta-analyses', Neuroscience and Biobehavioral Reviews, bind 126, s. 529-541. https://doi.org/10.1016/j.neubiorev.2021.03.034

APA

Anmella, G., Fico, G., Lotfaliany, M., Hidalgo-Mazzei, D., Soto-Angona, Ó., Giménez-Palomo, A., Amoretti, S., Murru, A., Radua, J., Solanes, A., Pacchiarotti, I., Verdolini, N., Cowdery, S., Dodd, S., Williams, L. J., Mohebbi, M., Carvalho, A. F., Kessing, L. V., Vieta, E., & Berk, M. (2021). Risk of cancer in bipolar disorder and the potential role of lithium: International collaborative systematic review and meta-analyses. Neuroscience and Biobehavioral Reviews, 126, 529-541. https://doi.org/10.1016/j.neubiorev.2021.03.034

CBE

Anmella G, Fico G, Lotfaliany M, Hidalgo-Mazzei D, Soto-Angona Ó, Giménez-Palomo A, Amoretti S, Murru A, Radua J, Solanes A, Pacchiarotti I, Verdolini N, Cowdery S, Dodd S, Williams LJ, Mohebbi M, Carvalho AF, Kessing LV, Vieta E, Berk M. 2021. Risk of cancer in bipolar disorder and the potential role of lithium: International collaborative systematic review and meta-analyses. Neuroscience and Biobehavioral Reviews. 126:529-541. https://doi.org/10.1016/j.neubiorev.2021.03.034

MLA

Vancouver

Author

Anmella, Gerard ; Fico, Giovanna ; Lotfaliany, Mojtaba ; Hidalgo-Mazzei, Diego ; Soto-Angona, Óscar ; Giménez-Palomo, Anna ; Amoretti, Silvia ; Murru, Andrea ; Radua, Joaquim ; Solanes, Aleix ; Pacchiarotti, Isabella ; Verdolini, Norma ; Cowdery, Stephanie ; Dodd, Seetal ; Williams, Lana J ; Mohebbi, Mohammadreza ; Carvalho, Andre F ; Kessing, Lars Vedel ; Vieta, Eduard ; Berk, Michael. / Risk of cancer in bipolar disorder and the potential role of lithium : International collaborative systematic review and meta-analyses. I: Neuroscience and Biobehavioral Reviews. 2021 ; Bind 126. s. 529-541.

Bibtex

@article{d4437c6cd8a94fe0bebcb91cf87d5695,
title = "Risk of cancer in bipolar disorder and the potential role of lithium: International collaborative systematic review and meta-analyses",
abstract = "We examined bipolar disorder (BD) as a risk factor for developing cancer and the role of lithium on cancer incidence. We conducted two systematic review and meta-analyses of population-based studies providing data on these associations. We screened articles indexed in MEDLINE, Scopus, Embase, and PsycINFO up to August 2020. The first random-effects meta-analysis, based on 4,910,661 individuals from nine studies estimated an increased risk of cancer of any kind [RR = 1.24 (1.05-1.46); p < 0.01], especially breast cancer [RR = 1.33 (1.15-1.55); p < 0.01] in BD. The second random-effects meta-analysis, based on 2,606,187 individuals from five studies did not show increased risk of cancer in people with BD using lithium, and even suggested a small protective effect both in overall [RR = 0.94 (0.72-1.22); p = 0.66] and urinary cancer [RR = 0.93 (0.75-1.14); p = 0.48] although these findings did not reach statistical significance. The current evidence highlights that cancer risk is increased in individuals with BD, particularly breast cancer in women. Lithium may have a potential protective effect on cancer, including urinary cancer. The role of lithium as a mainstay of treatment for BD is reinforced by this study.",
keywords = "Bipolar disorder, Breast cancer, Cancer, Lithium, Neuroscience, Psychiatry, Urinary cancer",
author = "Gerard Anmella and Giovanna Fico and Mojtaba Lotfaliany and Diego Hidalgo-Mazzei and {\'O}scar Soto-Angona and Anna Gim{\'e}nez-Palomo and Silvia Amoretti and Andrea Murru and Joaquim Radua and Aleix Solanes and Isabella Pacchiarotti and Norma Verdolini and Stephanie Cowdery and Seetal Dodd and Williams, {Lana J} and Mohammadreza Mohebbi and Carvalho, {Andre F} and Kessing, {Lars Vedel} and Eduard Vieta and Michael Berk",
note = "Copyright {\textcopyright} 2021 Elsevier Ltd. All rights reserved.",
year = "2021",
month = jul,
doi = "10.1016/j.neubiorev.2021.03.034",
language = "English",
volume = "126",
pages = "529--541",
journal = "Neuroscience & Biobehavioral Reviews",
issn = "0149-7634",
publisher = "Pergamon",

}

RIS

TY - JOUR

T1 - Risk of cancer in bipolar disorder and the potential role of lithium

T2 - International collaborative systematic review and meta-analyses

AU - Anmella, Gerard

AU - Fico, Giovanna

AU - Lotfaliany, Mojtaba

AU - Hidalgo-Mazzei, Diego

AU - Soto-Angona, Óscar

AU - Giménez-Palomo, Anna

AU - Amoretti, Silvia

AU - Murru, Andrea

AU - Radua, Joaquim

AU - Solanes, Aleix

AU - Pacchiarotti, Isabella

AU - Verdolini, Norma

AU - Cowdery, Stephanie

AU - Dodd, Seetal

AU - Williams, Lana J

AU - Mohebbi, Mohammadreza

AU - Carvalho, Andre F

AU - Kessing, Lars Vedel

AU - Vieta, Eduard

AU - Berk, Michael

N1 - Copyright © 2021 Elsevier Ltd. All rights reserved.

PY - 2021/7

Y1 - 2021/7

N2 - We examined bipolar disorder (BD) as a risk factor for developing cancer and the role of lithium on cancer incidence. We conducted two systematic review and meta-analyses of population-based studies providing data on these associations. We screened articles indexed in MEDLINE, Scopus, Embase, and PsycINFO up to August 2020. The first random-effects meta-analysis, based on 4,910,661 individuals from nine studies estimated an increased risk of cancer of any kind [RR = 1.24 (1.05-1.46); p < 0.01], especially breast cancer [RR = 1.33 (1.15-1.55); p < 0.01] in BD. The second random-effects meta-analysis, based on 2,606,187 individuals from five studies did not show increased risk of cancer in people with BD using lithium, and even suggested a small protective effect both in overall [RR = 0.94 (0.72-1.22); p = 0.66] and urinary cancer [RR = 0.93 (0.75-1.14); p = 0.48] although these findings did not reach statistical significance. The current evidence highlights that cancer risk is increased in individuals with BD, particularly breast cancer in women. Lithium may have a potential protective effect on cancer, including urinary cancer. The role of lithium as a mainstay of treatment for BD is reinforced by this study.

AB - We examined bipolar disorder (BD) as a risk factor for developing cancer and the role of lithium on cancer incidence. We conducted two systematic review and meta-analyses of population-based studies providing data on these associations. We screened articles indexed in MEDLINE, Scopus, Embase, and PsycINFO up to August 2020. The first random-effects meta-analysis, based on 4,910,661 individuals from nine studies estimated an increased risk of cancer of any kind [RR = 1.24 (1.05-1.46); p < 0.01], especially breast cancer [RR = 1.33 (1.15-1.55); p < 0.01] in BD. The second random-effects meta-analysis, based on 2,606,187 individuals from five studies did not show increased risk of cancer in people with BD using lithium, and even suggested a small protective effect both in overall [RR = 0.94 (0.72-1.22); p = 0.66] and urinary cancer [RR = 0.93 (0.75-1.14); p = 0.48] although these findings did not reach statistical significance. The current evidence highlights that cancer risk is increased in individuals with BD, particularly breast cancer in women. Lithium may have a potential protective effect on cancer, including urinary cancer. The role of lithium as a mainstay of treatment for BD is reinforced by this study.

KW - Bipolar disorder

KW - Breast cancer

KW - Cancer

KW - Lithium

KW - Neuroscience

KW - Psychiatry

KW - Urinary cancer

UR - http://www.scopus.com/inward/record.url?scp=85104292731&partnerID=8YFLogxK

U2 - 10.1016/j.neubiorev.2021.03.034

DO - 10.1016/j.neubiorev.2021.03.034

M3 - Review

C2 - 33831461

VL - 126

SP - 529

EP - 541

JO - Neuroscience & Biobehavioral Reviews

JF - Neuroscience & Biobehavioral Reviews

SN - 0149-7634

ER -

ID: 65849523