TY - JOUR
T1 - Risk of asthma in heterozygous carriers for cystic fibrosis
T2 - A meta-analysis
AU - Nielsen, Anne Orholm
AU - Qayum, Sadaf
AU - Bouchelouche, Pierre Nourdine
AU - Laursen, Lars Christian
AU - Dahl, Ronald
AU - Dahl, Morten
N1 - Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.
PY - 2016/9
Y1 - 2016/9
N2 - BACKGROUND: Patients with cystic fibrosis (CF) have a higher prevalence of asthma than the background population, however, it is unclear whether heterozygous CF carriers are susceptible to asthma. Given this, a meta-analysis is necessary to determine the veracity of the association of CF heterozygosity with asthma.METHODS: We screened the medical literature from 1966 to 2015 and performed a meta-analysis to determine the risk of asthma in CF heterozygotes vs. non-carriers.RESULTS: Aggregating data from 15 studies, the odds ratio for asthma in CF heterozygotes compared with non-carriers was significantly elevated at 1.61 (95% CI: 1.18-2.21). When analyzing the studies considered of high quality in which asthma was diagnosed by a physician, the patients were >18years, or study size was ≥500, the trend remained the same, that heterozygous carriers of CF had elevated risk for asthma.CONCLUSIONS: The results show that heterozygous carriers for CF have a higher risk of asthma than non-carriers.
AB - BACKGROUND: Patients with cystic fibrosis (CF) have a higher prevalence of asthma than the background population, however, it is unclear whether heterozygous CF carriers are susceptible to asthma. Given this, a meta-analysis is necessary to determine the veracity of the association of CF heterozygosity with asthma.METHODS: We screened the medical literature from 1966 to 2015 and performed a meta-analysis to determine the risk of asthma in CF heterozygotes vs. non-carriers.RESULTS: Aggregating data from 15 studies, the odds ratio for asthma in CF heterozygotes compared with non-carriers was significantly elevated at 1.61 (95% CI: 1.18-2.21). When analyzing the studies considered of high quality in which asthma was diagnosed by a physician, the patients were >18years, or study size was ≥500, the trend remained the same, that heterozygous carriers of CF had elevated risk for asthma.CONCLUSIONS: The results show that heterozygous carriers for CF have a higher risk of asthma than non-carriers.
KW - Journal Article
U2 - 10.1016/j.jcf.2016.06.001
DO - 10.1016/j.jcf.2016.06.001
M3 - Journal article
C2 - 27324553
VL - 15
SP - 563
EP - 567
JO - Journal of Cystic Fibrosis
JF - Journal of Cystic Fibrosis
SN - 1569-1993
IS - 5
ER -