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Region Hovedstaden - en del af Københavns Universitetshospital
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Risk factors for diagnostic delay in idiopathic pulmonary fibrosis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Validation of the IPF-specific version of St. George's Respiratory Questionnaire

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Prevalence and course of disease after lung resection in primary ciliary dyskinesia: a cohort & nested case-control study

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  3. Soluble urokinase plasminogen activator receptor predicts mortality in exacerbated COPD

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  4. Electronic applications for the CFQ-R scoring

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Increased respiratory morbidity in individuals with interstitial lung abnormalities

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Validation of the King's Brief Interstitial Lung Disease questionnaire in Idiopathic Pulmonary Fibrosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Validation of the IPF-specific version of St. George's Respiratory Questionnaire

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Background Surveys and retrospective studies of patients with idiopathic pulmonary fibrosis (IPF) have shown a significant diagnostic delay. However, the causes and risk factors for this delay are not known. Methods Dates at six time points before the IPF diagnosis (onset of symptoms, first contact to a general practitioner, first hospital contact, referral to an interstitial lung disease (ILD) centre, first visit at an ILD centre, and final diagnosis) were recorded in a multicentre cohort of 204 incident IPF patients. Based on these dates, the delay was divided into specific patient-related and healthcare-related delays. Demographic and clinical data were used to determine risk factors for a prolonged delay, using multivariate negative binomial regression analysis. Results The median diagnostic delay was 2.1 years (IQR: 0.9–5.0), mainly attributable to the patients, general practitioners and community hospitals. Male sex was a risk factor for patient delay (IRR: 3.84, 95% CI: 1.17–11.36, p = 0.006) and old age was a risk factor for healthcare delay (IRR: 1.03, 95% CI: 1.01–1.06, p = 0.004). The total delay was prolonged in previous users of inhalation therapy (IRR: 1.99, 95% CI: 1.40–2.88, p <  0.0001) but not in patients with airway obstruction. Misdiagnosis of respiratory symptoms was reported by 41% of all patients. Conclusion Despite increased awareness of IPF, the diagnostic delay is still 2.1 years. Male sex, older age and treatment attempts for alternative diagnoses are risk factors for a delayed diagnosis of IPF. Efforts to reduce the diagnostic delay should focus on these risk factors. Trial registration This study was registered at http://clinicaltrials.gov (NCT02772549) on May 10, 2016.
OriginalsprogEngelsk
TidsskriftRespiratory Research
Vol/bind20
Udgave nummer1
Sider (fra-til)103
ISSN1465-9921
DOI
StatusUdgivet - 24 maj 2019

ID: 59435750