Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Risk Factors for Chronic Cough Among 14 669 Individuals from the General Population

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. International Severe Asthma Registry: Mission Statement

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children with asthma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. An Integrative Transcriptomic and Metabolomic Study of Lung Function in Children With Asthma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Bariatric Surgery in Obese Patients With Psoriasis and COPD: Killing Three Birds With One Stone?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Genetic variation at PPP1R3B increases hepatic CT attenuation and interacts with prandial status on plasma glucose

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Tocilizumab and soluble interleukin-6 receptor in JAK2V617F somatic mutation and myeloproliferative neoplasm

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Impact of Glucose Level on Micro- and Macrovascular Disease in the General Population: A Mendelian Randomization Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Risk factors for chronic cough in the general population have not been described systematically. We identified and ranked chronic cough risk factors at the individual and community level using data from 14669 individuals from the Copenhagen General Population Study.

METHODS: Severity of chronic cough was assessed using the Leicester Cough Questionnaire(LCQ). We ranked chronic cough risk factors based on magnitude of age-adjusted odds ratios(ORs) at the individual level and of the population attributable risks(PARs) at the community level.

RESULTS: Prevalence of chronic cough in the general population was 4% overall and 3% in never-smokers, 4% in former smokers, and 8% in current smokers. Median score of the LCQ was 5.8(25 and 75 percentiles:5.0-6.3) for physical domain, 5.6(4.6-6.3) for psychological domain, 6.3 (5.5-6.8) for social domain, and 17.3(15.4-18.9) in total. At the level of the individual, age-adjusted ORs for the three top ranked risk factors were 5.0(95% CI:1.4-18) for bronchiectasis, 2.6(1.7-3.9) for asthma and 2.3(1.5-3.4) for gastroesophageal reflux disease in never-smokers, 7.1(2.6-20) for bronchiectasis, 3.1(2.2-4.4) for asthma and 2.2(1.5-3.2) for occupational exposure to dust/fumes in former smokers, and 1.9(1.3-2.9) for airflow limitation in current smokers. At the level of the community, the three top ranked risk factors were female sex (PAR:19%), asthma (10%) and gastroesophageal reflux disease (8%) in never-smokers, abdominal obesity (20%), low income (20%) and asthma (13%) in former smokers, and airflow limitation (23%) in current smokers.

CONCLUSIONS: Risk factors for chronic cough differ at the level of the individual and community, and by smoking status. Strategies to prevent and treat modifiable chronic cough risk factors should be tailored accordingly.

OriginalsprogEngelsk
TidsskriftChest
Vol/bind152
Udgave nummer3
Sider (fra-til)563-573
ISSN0012-3692
DOI
StatusUdgivet - 1 sep. 2017

ID: 50611735