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Risk factors for cardiovascular disease in 5-year survivors of adolescent and young adult cancer: A Danish population-based cohort study

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de Fine Licht, Sofie ; Maraldo, Maja V ; Specht, Lena ; Nielsen, Thomas T ; Winther, Jeanette F ; Rugbjerg, Kathrine. / Risk factors for cardiovascular disease in 5-year survivors of adolescent and young adult cancer : A Danish population-based cohort study. I: Cancer. 2020 ; Bind 126, Nr. 3. s. 659-669.

Bibtex

@article{b0a424bd32da4052819555e555ecceb7,
title = "Risk factors for cardiovascular disease in 5-year survivors of adolescent and young adult cancer: A Danish population-based cohort study",
abstract = "BACKGROUND: An increased risk of metabolic syndrome has been reported for childhood cancer survivors and for adult survivors with certain cancer types. One previous study reported on the risk for diseases in the metabolic syndrome specifically among survivors of adolescent and young adult cancers.METHODS: The study comprised 11,822 five-year survivors of adolescent and young adult cancer (ages 15-39 years at diagnosis) who were diagnosed during the period from 1994 through 2009 in Denmark and a population-based comparison cohort of 76,024 individuals. The cohorts were linked to Danish nationwide registries for information on hospital contacts and purchase of prescription drugs related to metabolic syndrome, respectively. Standardized rate ratios (RRs) for hospital contacts (SHRRs) and prescriptions (SPRRs) with 95{\%} CIs were calculated for diabetes, hyperlipidemia, and hypertension.RESULTS: Survivors had increased risks for hospital contacts and prescriptions for diabetes (SHRR, 1.21; 95{\%} CI, 1.03-1.43; SPRR, 1.08; 95{\%} CI, 0.96-1.23), hyperlipidemia (SHRR, 1.18; 95{\%} CI, 1.00-1.40; SPRR, 1.16; 95{\%} CI, 1.08-1.25), and hypertension (SHRR, 1.27; 95{\%} CI, 1.15-1.41; SPRR, 1.25; 95{\%} CI, 1.20-1.31). The highest risks for hospitalizations were among survivors of brain cancer (RR, 2.94 for diabetes) and Hodgkin lymphoma (RR, 2.40 for diabetes). Survivors of brain cancer and Hodgkin lymphoma were most likely to purchase prescription drugs for diseases in metabolic syndrome.CONCLUSIONS: Survivors of adolescent and young adult cancer are at increased risk of hospital contacts and purchase of prescription drugs for diseases in metabolic syndrome. Survivors at high risk should be followed closely to improve prevention, early detection, and management of these diseases to ultimately minimize the risk of cardiovascular diseases.",
keywords = "adolescents and young adults, diabetes, hyperlipidemia, hypertension, metabolic syndrome",
author = "{de Fine Licht}, Sofie and Maraldo, {Maja V} and Lena Specht and Nielsen, {Thomas T} and Winther, {Jeanette F} and Kathrine Rugbjerg",
note = "{\circledC} 2019 American Cancer Society.",
year = "2020",
month = "2",
day = "1",
doi = "10.1002/cncr.32580",
language = "English",
volume = "126",
pages = "659--669",
journal = "Cancer",
issn = "0008-543X",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Risk factors for cardiovascular disease in 5-year survivors of adolescent and young adult cancer

T2 - A Danish population-based cohort study

AU - de Fine Licht, Sofie

AU - Maraldo, Maja V

AU - Specht, Lena

AU - Nielsen, Thomas T

AU - Winther, Jeanette F

AU - Rugbjerg, Kathrine

N1 - © 2019 American Cancer Society.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - BACKGROUND: An increased risk of metabolic syndrome has been reported for childhood cancer survivors and for adult survivors with certain cancer types. One previous study reported on the risk for diseases in the metabolic syndrome specifically among survivors of adolescent and young adult cancers.METHODS: The study comprised 11,822 five-year survivors of adolescent and young adult cancer (ages 15-39 years at diagnosis) who were diagnosed during the period from 1994 through 2009 in Denmark and a population-based comparison cohort of 76,024 individuals. The cohorts were linked to Danish nationwide registries for information on hospital contacts and purchase of prescription drugs related to metabolic syndrome, respectively. Standardized rate ratios (RRs) for hospital contacts (SHRRs) and prescriptions (SPRRs) with 95% CIs were calculated for diabetes, hyperlipidemia, and hypertension.RESULTS: Survivors had increased risks for hospital contacts and prescriptions for diabetes (SHRR, 1.21; 95% CI, 1.03-1.43; SPRR, 1.08; 95% CI, 0.96-1.23), hyperlipidemia (SHRR, 1.18; 95% CI, 1.00-1.40; SPRR, 1.16; 95% CI, 1.08-1.25), and hypertension (SHRR, 1.27; 95% CI, 1.15-1.41; SPRR, 1.25; 95% CI, 1.20-1.31). The highest risks for hospitalizations were among survivors of brain cancer (RR, 2.94 for diabetes) and Hodgkin lymphoma (RR, 2.40 for diabetes). Survivors of brain cancer and Hodgkin lymphoma were most likely to purchase prescription drugs for diseases in metabolic syndrome.CONCLUSIONS: Survivors of adolescent and young adult cancer are at increased risk of hospital contacts and purchase of prescription drugs for diseases in metabolic syndrome. Survivors at high risk should be followed closely to improve prevention, early detection, and management of these diseases to ultimately minimize the risk of cardiovascular diseases.

AB - BACKGROUND: An increased risk of metabolic syndrome has been reported for childhood cancer survivors and for adult survivors with certain cancer types. One previous study reported on the risk for diseases in the metabolic syndrome specifically among survivors of adolescent and young adult cancers.METHODS: The study comprised 11,822 five-year survivors of adolescent and young adult cancer (ages 15-39 years at diagnosis) who were diagnosed during the period from 1994 through 2009 in Denmark and a population-based comparison cohort of 76,024 individuals. The cohorts were linked to Danish nationwide registries for information on hospital contacts and purchase of prescription drugs related to metabolic syndrome, respectively. Standardized rate ratios (RRs) for hospital contacts (SHRRs) and prescriptions (SPRRs) with 95% CIs were calculated for diabetes, hyperlipidemia, and hypertension.RESULTS: Survivors had increased risks for hospital contacts and prescriptions for diabetes (SHRR, 1.21; 95% CI, 1.03-1.43; SPRR, 1.08; 95% CI, 0.96-1.23), hyperlipidemia (SHRR, 1.18; 95% CI, 1.00-1.40; SPRR, 1.16; 95% CI, 1.08-1.25), and hypertension (SHRR, 1.27; 95% CI, 1.15-1.41; SPRR, 1.25; 95% CI, 1.20-1.31). The highest risks for hospitalizations were among survivors of brain cancer (RR, 2.94 for diabetes) and Hodgkin lymphoma (RR, 2.40 for diabetes). Survivors of brain cancer and Hodgkin lymphoma were most likely to purchase prescription drugs for diseases in metabolic syndrome.CONCLUSIONS: Survivors of adolescent and young adult cancer are at increased risk of hospital contacts and purchase of prescription drugs for diseases in metabolic syndrome. Survivors at high risk should be followed closely to improve prevention, early detection, and management of these diseases to ultimately minimize the risk of cardiovascular diseases.

KW - adolescents and young adults

KW - diabetes

KW - hyperlipidemia

KW - hypertension

KW - metabolic syndrome

U2 - 10.1002/cncr.32580

DO - 10.1002/cncr.32580

M3 - Journal article

VL - 126

SP - 659

EP - 669

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 3

ER -

ID: 58967961