RhoC a new target for therapeutic vaccination against metastatic cancer

Lynn Wenandy, Rikke Baek Sørensen, Inge Marie Svane, Per Thor Straten, Mads Hald Andersen

Abstract

Most cancer deaths are due to the development of metastases. Increased expression of RhoC is linked to enhanced metastatic potential in multiple cancers. Consequently, the RhoC protein is an attractive target for drug design. The clinical application of immunotherapy against cancer is rapidly moving forward in multiple areas, including the adoptive transfer of anti-tumor-reactive T cells and the use of "therapeutic" vaccines. The over-expression of RhoC in cancer and the fact that immune escape by down regulation or loss of expression of this protein would reduce the morbidity and mortality of cancer makes RhoC a very attractive target for anti-cancer immunotherapy. Herein, we describe an HLA-A3 restricted epitope from RhoC, which is recognized by cytotoxic T cells. Moreover, RhoC-specific T cells show cytotoxic potential against HLA-matched cancer cells of different origin. Thus, RhoC may serve as an important and widely applicable target for anti-cancer immunotherapeutic strategies.

OriginalsprogEngelsk
TidsskriftCancer Immunology and Immunotherapy
Vol/bind57
Udgave nummer12
Sider (fra-til)1871-8
Antal sider8
ISSN0340-7004
DOI
StatusUdgivet - dec. 2008

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