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Rheumatoid arthritis and risk of spontaneous abortion: a Danish nationwide cohort study

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@article{f80927ff93804de58ab0b1368cff28cd,
title = "Rheumatoid arthritis and risk of spontaneous abortion: a Danish nationwide cohort study",
abstract = "OBJECTIVES: To investigate the influence of RA or preclinical RA on the risk of spontaneous abortion (SA) while taking age and duration of RA into consideration. METHODS: By linkage of data from Danish national registries, we established a nationwide cohort of pregnancies in Denmark from 1 January 1977 to 31 December 2014. We used multiple logistic regression to estimate; odds ratios (OR) for SA in women with RA or preclinical RA, compared with women without, and OR for SA by maternal age in women with RA or preclinical RA. RESULTS: A total of 2 612 529 pregnancies were included. Women aged <35 years diagnosed with RA <5 years before pregnancy had an increased risk of SA (OR = 1.25 95% CI: 1.07, 1.48), compared with women without RA aged <35. Women at the same age diagnosed with RA ≥5 years before pregnancy had an OR of 1.14 (0.96-1.34), compared with women without. Among women with RA aged ≥35 years and women with preclinical RA at time of pregnancy, no increased risk of SA was found. The risk of SA increased by maternal age in both women with RA, preclinical RA and in women without. CONCLUSION: Among women aged <35 years, the risk of SA was higher in women with RA compared with women without. After the age of 35 years, the risk of SA was no different from that among women without RA, even though the risk of SA increased with increasing age.",
keywords = "maternal age, preclinical rheumatoid arthritis, pregnancy, rheumatoid arthritis, spontaneous abortion",
author = "Nathan, {Nina O} and M{\o}rch, {Lina S} and Wu, {Chun S} and J{\o}rn Olsen and Hetland, {Merete L} and Jiong Li and Rom, {Ane L}",
note = "COPECARE",
year = "2020",
month = aug,
day = "1",
doi = "10.1093/rheumatology/kez565",
language = "English",
volume = "59",
pages = "1984--1991",
journal = "Rheumatology (Online)",
issn = "1462-0332",
publisher = "Oxford University Press",
number = "8",

}

RIS

TY - JOUR

T1 - Rheumatoid arthritis and risk of spontaneous abortion

T2 - a Danish nationwide cohort study

AU - Nathan, Nina O

AU - Mørch, Lina S

AU - Wu, Chun S

AU - Olsen, Jørn

AU - Hetland, Merete L

AU - Li, Jiong

AU - Rom, Ane L

N1 - COPECARE

PY - 2020/8/1

Y1 - 2020/8/1

N2 - OBJECTIVES: To investigate the influence of RA or preclinical RA on the risk of spontaneous abortion (SA) while taking age and duration of RA into consideration. METHODS: By linkage of data from Danish national registries, we established a nationwide cohort of pregnancies in Denmark from 1 January 1977 to 31 December 2014. We used multiple logistic regression to estimate; odds ratios (OR) for SA in women with RA or preclinical RA, compared with women without, and OR for SA by maternal age in women with RA or preclinical RA. RESULTS: A total of 2 612 529 pregnancies were included. Women aged <35 years diagnosed with RA <5 years before pregnancy had an increased risk of SA (OR = 1.25 95% CI: 1.07, 1.48), compared with women without RA aged <35. Women at the same age diagnosed with RA ≥5 years before pregnancy had an OR of 1.14 (0.96-1.34), compared with women without. Among women with RA aged ≥35 years and women with preclinical RA at time of pregnancy, no increased risk of SA was found. The risk of SA increased by maternal age in both women with RA, preclinical RA and in women without. CONCLUSION: Among women aged <35 years, the risk of SA was higher in women with RA compared with women without. After the age of 35 years, the risk of SA was no different from that among women without RA, even though the risk of SA increased with increasing age.

AB - OBJECTIVES: To investigate the influence of RA or preclinical RA on the risk of spontaneous abortion (SA) while taking age and duration of RA into consideration. METHODS: By linkage of data from Danish national registries, we established a nationwide cohort of pregnancies in Denmark from 1 January 1977 to 31 December 2014. We used multiple logistic regression to estimate; odds ratios (OR) for SA in women with RA or preclinical RA, compared with women without, and OR for SA by maternal age in women with RA or preclinical RA. RESULTS: A total of 2 612 529 pregnancies were included. Women aged <35 years diagnosed with RA <5 years before pregnancy had an increased risk of SA (OR = 1.25 95% CI: 1.07, 1.48), compared with women without RA aged <35. Women at the same age diagnosed with RA ≥5 years before pregnancy had an OR of 1.14 (0.96-1.34), compared with women without. Among women with RA aged ≥35 years and women with preclinical RA at time of pregnancy, no increased risk of SA was found. The risk of SA increased by maternal age in both women with RA, preclinical RA and in women without. CONCLUSION: Among women aged <35 years, the risk of SA was higher in women with RA compared with women without. After the age of 35 years, the risk of SA was no different from that among women without RA, even though the risk of SA increased with increasing age.

KW - maternal age

KW - preclinical rheumatoid arthritis

KW - pregnancy

KW - rheumatoid arthritis

KW - spontaneous abortion

U2 - 10.1093/rheumatology/kez565

DO - 10.1093/rheumatology/kez565

M3 - Journal article

C2 - 31776579

VL - 59

SP - 1984

EP - 1991

JO - Rheumatology (Online)

JF - Rheumatology (Online)

SN - 1462-0332

IS - 8

ER -

ID: 60979697