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E-pub ahead of print

Review A State of Natriuretic Peptide Deficiency

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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Measurement of natriuretic peptides (NPs) has proven its clinical value as biomarker, especially in the context of heart failure (HF). In contrast, a state partial NP deficiency appears integral to several conditions in which lower NP concentrations in plasma presage overt cardiometabolic disease. Here, obesity and type 2 diabetes have attracted considerable attention. Other factors - including age, sex, race, genetics, and diurnal regulation - affect the NP "armory" and may leave some individuals more prone to development of cardiovascular disease. The molecular maturation of NPs has also proven complex with highly variable O-glycosylation within the biosynthetic precursors. The relevance of this regulatory step in post-translational propeptide maturation has recently become recognized in biomarker measurement/interpretation and cardiovascular pathophysiology. An important proportion of people appear to have reduced effective net NP bioactivity in terms of receptor activation and physiological effects. The state of NP deficiency, then, both entails a potential for further biomarker development and could also offer novel pharmacological possibilities. Alleviating the state of NP deficiency before development of overt cardiometabolic disease in selected patients could be a future path for improving precision medicine.

OriginalsprogEngelsk
TidsskriftEndocrine Reviews
ISSN0163-769X
DOI
StatusE-pub ahead of print - 8 nov. 2022

Bibliografisk note

© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.

ID: 85791865