TY - JOUR
T1 - Reversible audiometric threshold changes in children with uncomplicated malaria
AU - Adjei, George O
AU - Goka, Bamenla Q
AU - Kitcher, Emmanuel
AU - Rodrigues, Onike P
AU - Badoe, Ebenezer
AU - Kurtzhals, Jorgen A L
PY - 2013/3/7
Y1 - 2013/3/7
N2 - Background. Plasmodium falciparum malaria, as well as certain antimalarial drugs, is associated with hearing impairment in adults. There is little information, however, on the extent, if any, of this effect in children, and the evidence linking artemisinin combination therapies (ACTs) with hearing is inconclusive. Methods. Audiometry was conducted in children with uncomplicated malaria treated with artesunate-amodiaquine (n = 37), artemether-lumefantrine (n = 35), or amodiaquine (n = 8) in Accra, Ghana. Audiometry was repeated 3, 7, and 28 days later and after 9 months. Audiometric thresholds were compared with those of a control group of children (n = 57) from the same area. Findings. During the acute stage, hearing threshold levels of treated children were significantly elevated compared with controls (P
AB - Background. Plasmodium falciparum malaria, as well as certain antimalarial drugs, is associated with hearing impairment in adults. There is little information, however, on the extent, if any, of this effect in children, and the evidence linking artemisinin combination therapies (ACTs) with hearing is inconclusive. Methods. Audiometry was conducted in children with uncomplicated malaria treated with artesunate-amodiaquine (n = 37), artemether-lumefantrine (n = 35), or amodiaquine (n = 8) in Accra, Ghana. Audiometry was repeated 3, 7, and 28 days later and after 9 months. Audiometric thresholds were compared with those of a control group of children (n = 57) from the same area. Findings. During the acute stage, hearing threshold levels of treated children were significantly elevated compared with controls (P
U2 - 10.1155/2013/360540
DO - 10.1155/2013/360540
M3 - Journal article
C2 - 23554819
SN - 1687-9686
VL - 2013
SP - 360540
JO - Journal of Tropical Medicine
JF - Journal of Tropical Medicine
ER -