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Reversal of profound, high-dose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose-finding, safety assessor-blinded, phase II trial

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@article{9d0f29877972427fbbea2ca6805442c9,
title = "Reversal of profound, high-dose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose-finding, safety assessor-blinded, phase II trial",
abstract = "Sugammadex (Org 25969), a novel, selective relaxant binding agent, was specifically designed to rapidly reverse rocuronium-induced neuromuscular blockade. The efficacy and safety of sugammadex for the reversal of profound, high-dose rocuronium-induced neuromuscular blockade was evaluated.",
keywords = "Androstanols, Anesthesia, Intravenous, Anesthetics, Intravenous, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Toxicity, Female, Humans, Male, Middle Aged, Neuromuscular Blockade, Neuromuscular Depolarizing Agents, Propofol, gamma-Cyclodextrins",
author = "P{\"u}hringer, {Friedrich K} and Christopher Rex and Sielenk{\"a}mper, {Andreas W} and Casper Claudius and Larsen, {Per Bo} and Prins, {Martine E} and Matthias Eikermann and Khuenl-Brady, {Karin S}",
year = "2008",
month = "8",
day = "1",
doi = "10.1097/ALN.0b013e31817f5bc7",
language = "English",
volume = "109",
pages = "188--97",
journal = "Anesthesiology News",
issn = "0747-4679",
publisher = "McMahon Group",
number = "2",

}

RIS

TY - JOUR

T1 - Reversal of profound, high-dose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose-finding, safety assessor-blinded, phase II trial

AU - Pühringer, Friedrich K

AU - Rex, Christopher

AU - Sielenkämper, Andreas W

AU - Claudius, Casper

AU - Larsen, Per Bo

AU - Prins, Martine E

AU - Eikermann, Matthias

AU - Khuenl-Brady, Karin S

PY - 2008/8/1

Y1 - 2008/8/1

N2 - Sugammadex (Org 25969), a novel, selective relaxant binding agent, was specifically designed to rapidly reverse rocuronium-induced neuromuscular blockade. The efficacy and safety of sugammadex for the reversal of profound, high-dose rocuronium-induced neuromuscular blockade was evaluated.

AB - Sugammadex (Org 25969), a novel, selective relaxant binding agent, was specifically designed to rapidly reverse rocuronium-induced neuromuscular blockade. The efficacy and safety of sugammadex for the reversal of profound, high-dose rocuronium-induced neuromuscular blockade was evaluated.

KW - Androstanols

KW - Anesthesia, Intravenous

KW - Anesthetics, Intravenous

KW - Dose-Response Relationship, Drug

KW - Drug Administration Schedule

KW - Drug Toxicity

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Neuromuscular Blockade

KW - Neuromuscular Depolarizing Agents

KW - Propofol

KW - gamma-Cyclodextrins

U2 - 10.1097/ALN.0b013e31817f5bc7

DO - 10.1097/ALN.0b013e31817f5bc7

M3 - Journal article

VL - 109

SP - 188

EP - 197

JO - Anesthesiology News

JF - Anesthesiology News

SN - 0747-4679

IS - 2

ER -

ID: 32797431