Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Retinal arteriolar wall-to-lumen ratios at 16-17 years in the Copenhagen Child Cohort 2000 Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Obesity remains a major risk factor associated with vascular stiffening in type 2 diabetes

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

  2. Impact of age on the association between 24-h ambulatory blood pressure measurements and target organ damage

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Reply: Is automated screening for DR indeed not yet ready as stated by Grauslund et al?

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. Spectral-domain optical coherence tomography of retinal vessels in Waldenström's macroglobulinemia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. An Expanded Test Panel for Assessment of Fringe Benefits From Cataract Surgery

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

Vis graf over relationer

PURPOSE: To study the thickness of retinal arteriolar walls in a population-based cohort of adolescents.

METHODS: This cross-sectional, observational study included 1217 participants aged 16-17 years from the Copenhagen Child Cohort 2000 Study. The wall thickness and lumen diameter of a major branch retinal arteriole were measured using adaptive optics imaging. The wall-to-lumen ratio was analyzed in relation to blood pressure and body composition variables using a general linear model. Overall in the study population, wall-to-lumen ratio was found to decrease by 0.49% per μm increase in arteriole diameter (P < 0.0001) and all subsequent analyzes were adjusted accordingly.

RESULTS: The average outer and inner arteriole diameters were 117 ± 19 and 96.6 ± 18 μm (mean ± SD), corresponding to a wall-to-lumen ratio of 0.21 ± 0.024. There was no detectable difference between sexes. A higher wall-to-lumen ratio was associated with a higher BMI (+0.21% per kg/m, P = 0.0018), higher body fat percentage (+0.097% per 1% increase, P = 0.0052), wider hip circumference (+1.1% per 10 cm increase, P = 0.0006), wider waist circumference (+0.92% per 10 cm increase, P = 0.0009), higher SBP in girls (+1.1% per 10 mmHg increase, P = 0.0005), longer axial length (+0.70% per mm increase, P = 0.013), and younger age (+4.9% per year younger, P < 0.0001), adjusted for arteriole diameter, age, sex, and height.

CONCLUSION: A higher retinal arteriolar wall-to-lumen ratio was associated with all registered indices of body fat proportion.

TidsskriftJournal of Hypertension
Udgave nummer4
Sider (fra-til)731-736
Antal sider6
StatusUdgivet - 2020

ID: 58627395