Retigabine: chemical synthesis to clinical application

Keyphrases

• 2-amino-4 12%
• Action Potential Generation 12%
• Adverse Effects 12%
• Allodynia 12%
• Amygdala Kindling 25%
• Analgesic 12%
• Animal Models of Anxiety 12%
• Antiepileptic Drugs 25%
• Anxiety-like Behavior 25%
• Carbamic Acid 12%
• Chemical Synthesis 100%
• Chemically Induced 12%
• Clinical Application 100%
• Difficult-to-treat 12%
• Disease States 12%
• Disease-associated 12%
• Dizziness 12%
• Dose-ranging 12%
• Early Phase Clinical Trials 12%
• Epileptic Seizure 12%
• Ethyl Esters 12%
• First-pass Metabolism 12%
• Headache 12%
• Hyperalgesia 12%
• K Channels 12%
• K+ Current 12%
• KCNQ2 12%
• M-current 12%
• Marble Burying Test 12%
• Maximal Electroshock 12%
• Membrane Potential 12%
• Nausea 12%
• Neuronal Activation 25%
• Neuronal Excitability 12%
• Neuronal Hyperexcitability 25%
• Neuropathic Pain 37%
• Novel Mechanism of Action 12%
• Pain Behavior 12%
• Pain Conditions 12%
• Pain Transmission 12%
• Pathological Changes 12%
• Pentylenetetrazole 12%
• Phenyl 12%
• Picrotoxin 12%
• Relieve Pain 12%
• Retigabine 100%
• Sensory Pathways 12%
• Somnolence 12%
• Spectrum of Activity 12%
• Subthreshold 12%
• Therapeutic Agents 12%
• Tolerability 12%
• Voltage-dependent Activation 12%
• Zero Maze 12%

Pharmacology, Toxicology and Pharmaceutical Science

• Adverse Event 11%
• Allodynia 11%
• Analgesic Agent 11%
• Anticonvulsive Agent 11%
• Clinical Study 11%
• Disease 22%
• Dizziness 11%
• Electric Shock 11%
• Ethyl Carbamate 11%
• First Pass Effect 11%
• Headache 11%
• Hyperalgesia 11%
• Mouse 11%
• N Methyl Dextro Aspartic Acid 11%
• Nausea 11%
• Neuropathic Pain 33%
• Pentetrazole 11%
• Picrotoxin 11%
• Retigabine 100%
• Seizure 11%
• Somnolence 11%
• Symptom 11%
• Tolerability 11%