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Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men

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Vis graf over relationer
Ageing is thought to be associated with decreased vascular function partly due to oxidative stress. Resveratrol is a polyphenol, which in animal studies has been shown to decrease atherosclerosis, and improve cardiovascular health and physical capacity, in part through its effects on Sirtuin 1 signalling and through an improved antioxidant capacity. We tested the hypothesis that resveratrol supplementation enhances training-induced improvements in cardiovascular health parameters in aged men. Twenty-seven healthy physically inactive aged men (age: 65 ± 1 years; body mass index: 25.4 ± 0.7 kg m(-2); mean arterial pressure (MAP): 95.8 ± 2.2 mmHg; maximal oxygen uptake: 2488 ± 72 ml O2 min(-1)) were randomized into 8 weeks of either daily intake of either 250 mg trans-resveratrol (n = 14) or of placebo (n = 13) concomitant with high-intensity exercise training. Exercise training led to a 45% greater (P
OriginalsprogEngelsk
TidsskriftThe Journal of physiology
Vol/bind591
Udgave nummerPt 20
Sider (fra-til)5047-59
Antal sider13
ISSN0022-3751
DOI
StatusUdgivet - 15 okt. 2013

ID: 43148425