TY - JOUR
T1 - Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men
AU - Gliemann, Lasse
AU - Schmidt, Jakob Friis
AU - Olesen, Jesper
AU - Biensø, Rasmus Sjørup
AU - Peronard, Sebastian Louis
AU - Grandjean, Simon Udsen
AU - Mortensen, Stefan Peter
AU - Nyberg, Michael
AU - Bangsbo, Jens
AU - Pilegaard, Henriette
AU - Hellsten, Ylva
PY - 2013/10/15
Y1 - 2013/10/15
N2 - Ageing is thought to be associated with decreased vascular function partly due to oxidative stress. Resveratrol is a polyphenol, which in animal studies has been shown to decrease atherosclerosis, and improve cardiovascular health and physical capacity, in part through its effects on Sirtuin 1 signalling and through an improved antioxidant capacity. We tested the hypothesis that resveratrol supplementation enhances training-induced improvements in cardiovascular health parameters in aged men. Twenty-seven healthy physically inactive aged men (age: 65 ± 1 years; body mass index: 25.4 ± 0.7 kg m(-2); mean arterial pressure (MAP): 95.8 ± 2.2 mmHg; maximal oxygen uptake: 2488 ± 72 ml O2 min(-1)) were randomized into 8 weeks of either daily intake of either 250 mg trans-resveratrol (n = 14) or of placebo (n = 13) concomitant with high-intensity exercise training. Exercise training led to a 45% greater (P
AB - Ageing is thought to be associated with decreased vascular function partly due to oxidative stress. Resveratrol is a polyphenol, which in animal studies has been shown to decrease atherosclerosis, and improve cardiovascular health and physical capacity, in part through its effects on Sirtuin 1 signalling and through an improved antioxidant capacity. We tested the hypothesis that resveratrol supplementation enhances training-induced improvements in cardiovascular health parameters in aged men. Twenty-seven healthy physically inactive aged men (age: 65 ± 1 years; body mass index: 25.4 ± 0.7 kg m(-2); mean arterial pressure (MAP): 95.8 ± 2.2 mmHg; maximal oxygen uptake: 2488 ± 72 ml O2 min(-1)) were randomized into 8 weeks of either daily intake of either 250 mg trans-resveratrol (n = 14) or of placebo (n = 13) concomitant with high-intensity exercise training. Exercise training led to a 45% greater (P
U2 - 10.1113/jphysiol.2013.258061
DO - 10.1113/jphysiol.2013.258061
M3 - Journal article
C2 - 23878368
SN - 0022-3751
VL - 591
SP - 5047
EP - 5059
JO - The Journal of physiology
JF - The Journal of physiology
IS - Pt 20
ER -