Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Restoration of enteroendocrine and pancreatic function after internal hernia and short bowel syndrome in a young woman with gastric bypass - a 2-year follow-up

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Age-dependent impairment of the erythropoietin response to reduced central venous pressure in HFpEF patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Glucagon-like peptide-1 elicts vasodilation in adipose tissue and skeletal muscle in healthy men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The Effects of Dual GLP-1/GIP Receptor Agonism on Glucagon Secretion-A Review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Pros and cons of Roux en-Y gastric bypass surgery in obese patients with type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Glucagon Receptor Signaling and Glucagon Resistance

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Continuous glucose monitoring in pregnant women with type 1 diabetes: an observational cohort study of 186 pregnancies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

A serious complication to the laparoscopic Roux-en-Y gastric bypass (RYGB) is internal hernia, which can lead to massive bowel necrosis that may result in short bowel syndrome. We determined postprandial enteropancreatic hormonal responses and metabolites in a 22-year-old nondiabetic woman with a history of RYGB experiencing severe internal herniation with widespread bowel necrosis. Extensive resections were performed leaving her with a saliva fistula from the pouch-enteric anastomosis, an intact duodenum, 15 cm of jejunum, 35 cm of ileum, and intact colon. Parenteral nutrition was initiated and 10 months after the bowel resection, intestinal continuity was re-established. After 6 weeks the patient reached parenteral nutrition independence. She underwent standardized liquid mixed meal tests before, 3 months after and 2 years after intestinal continuity was re-established. Gut hormone responses were completely restored postoperatively leading to very high concentrations in plasma. After 2 years, plasma concentrations had, however, decreased markedly, suggesting desensitization of the gut ostensibly in response to chronic hyperstimulation. There was no evidence of cephalic phase insulin secretion.

OriginalsprogEngelsk
TidsskriftPhysiological Reports
Vol/bind6
Udgave nummer9
Sider (fra-til)e13686
ISSN2051-817X
DOI
StatusUdgivet - maj 2018

ID: 53734208