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Responsiveness and minimal clinically important difference of SGRQ-I and K-BILD in idiopathic pulmonary fibrosis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Validation of a derived version of the IPF-specific Saint George’s Respiratory Questionnaire

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Long-term predictors of severe exacerbations and mortality in a cohort of well-characterised adults with asthma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Turnover of type I and III collagen predicts progression of idiopathic pulmonary fibrosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. A New Pathogenic Variant of the RTEL1 Gene and Dyskeratosis Congenita: A Dermatological View

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Validation of a derived version of the IPF-specific Saint George’s Respiratory Questionnaire

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Clusters of comorbidities in idiopathic pulmonary fibrosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Turnover of type I and III collagen predicts progression of idiopathic pulmonary fibrosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Background: Idiopathic pulmonary fibrosis (IPF) specific version of St. George's Respiratory Questionnaire (SGRQ-I) and King's Brief Interstitial Lung Disease questionnaire (K-BILD) are validated health-related quality of life (HRQL) instruments, but no or limited data exist on their responsiveness and minimal clinically important difference (MCID). The objectives of this study were to assess responsiveness of SGRQ-I and K-BILD and determine MCID separately for deterioration and improvement in a large, prospective cohort of patients with IPF in a real-world setting. Methods: Consecutive patients with IPF were recruited. SGRQ-I, K-BILD, SGRQ, Shortness of Breath Questionnaire, pulmonary function tests and 6-min walk test measurements were obtained at baseline and at six and 12 months; at six and 12 months, patients also completed Global Rating of Change Scales. Responsiveness was assessed using correlation coefficients and linear regression. Cox regression was used for mortality analyses. MCID was estimated using receiver operating characteristic curves with separate analyses for improvement and deterioration. Results: A total of 150 IPF patients were included and 124 completed the 12-month follow-up. Based on all HRQL anchors and most physiological anchors, responsiveness analyses supported the evidence pointing towards SGRQ-I and K-BILD as responsive instruments. Multivariate analyses showed an association between SGRQ-I and mortality (HR: 1.18, 95% CI: 1.02 to 1.36, p = 0.03) and a trend was found for K-BILD (HR: 0.82, 95% CI: 0.64 to 1.05, p = 0.12). MCID was estimated for all domains of SGRQ-I and K-BILD. MCID for improvement differed from deterioration for both SGRQ-I Total (3.9 and 4.9) and K-BILD Total (4.7 and 2.7). Conclusions: SGRQ-I and K-BILD were responsive to change concerning both HRQL and most physiological anchors. MCID was determined separately for improvement and deterioration, resulting in different estimates; especially a smaller estimate for deterioration compared to improvement in K-BILD. Trial registration: Clinicaltrials.gov, no. NCT02818712. Registered 30 June 2016.

OriginalsprogEngelsk
Artikelnummer91
TidsskriftRespiratory Research
Vol/bind21
Udgave nummer1
Sider (fra-til)91
ISSN1465-9921
DOI
StatusUdgivet - 21 apr. 2020

ID: 61897607