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Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Respiratory Syncytial Virus-Associated Hospital Admissions and Bed Days in Children

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  • Xin Wang
  • You Li
  • Liliana Vazquez Fernandez
  • Anne C Teirlinck
  • Toni Lehtonen
  • Maarten van Wijhe
  • Luca Stona
  • Mathieu Bangert
  • Rachel M Reeves
  • Håkon Bøås
  • Michiel van Boven
  • Terho Heikkinen
  • Caroline Klint Johannesen
  • Eugenio Baraldi
  • Daniele Donà
  • Sabine Tong
  • Harry Campbell
  • REspiratory Syncytial virus Consortium in EUrope (RESCEU) Investigators
  • Thea Kølsen Fischer (Medlem af forfattergruppering)
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BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infections (RTIs) in young children. High-quality country-specific estimates of bed days and length of stay (LOS) show the population burden of RSV-RTI on secondary care services and the burden among patients, and can be used to inform RSV immunization implementation decisions.

METHODS: We estimated the hospital burden of RSV-associated RTI (RSV-RTI) in children under 5 years in 7 European countries (Finland, Denmark, Norway, Scotland, England, the Netherlands, and Italy) using routinely collected hospital databases during 2001-2018. We described RSV-RTI admission rates during the first year of life by birth month and assessed their correlation with RSV seasonality in 5 of the countries (except for England and Italy). We estimated average annual numbers and rates of bed days for RSV-RTI and other-pathogen RTI, as well as the hospital LOS.

RESULTS: We found that infants born 2 months before the peak month of RSV epidemics more frequently had the highest RSV-RTI hospital admission rate. RSV-RTI hospital episodes accounted for 9.9-21.2 bed days per 1000 children aged <5 years annually, with the median (interquartile range) LOS ranging from 2 days (0.5-4 days) to 4 days (2-6 days) between countries. Between 70% and 89% of these bed days were in infants aged <1 year, representing 40.3 (95% confidence interval [CI], 40.1-40.4) to 91.2 (95% CI, 90.6-91.8) bed days per 1000 infants annually. The number of bed days for RSV-RTI was higher than that for RTIs associated with other pathogens in infants aged <1 year, especially in those <6 months.

CONCLUSIONS: RSV disease prevention therapies (monoclonal antibodies and maternal vaccines) for infants could help prevent a substantial number of bed days due to RSV-RTI. "High-risk" birth months should be considered when developing RSV immunization schedules. Variation in LOS between countries might reflect differences in hospital care practices.

OriginalsprogEngelsk
TidsskriftThe Journal of infectious diseases
ISSN0022-1899
DOI
StatusE-pub ahead of print - 12 jan. 2022

Bibliografisk note

© The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

ID: 70952837