TY - JOUR
T1 - Respiratory Syncytial Virus-Associated Hospital Admissions in Children Younger Than 5 Years in 7 European Countries Using Routinely Collected Datasets
AU - Reeves, Rachel M
AU - van Wijhe, Maarten
AU - Tong, Sabine
AU - Lehtonen, Toni
AU - Stona, Luca
AU - Teirlinck, Anne C
AU - Fernandez, Liliana Vazquez
AU - Li, You
AU - Giaquinto, Carlo
AU - Fischer, Thea Kølsen
AU - Demont, Clarisse
AU - Heikkinen, Terho
AU - Speltra, Irene
AU - van Boven, Michiel
AU - Bøås, Håkon
AU - Campbell, Harry
AU - RESCEU Investigators
N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].
PY - 2020/10/7
Y1 - 2020/10/7
N2 - BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infection (RTI) in young children. Registries provide opportunities to explore RSV epidemiology and burden.METHODS: We explored routinely collected hospital data on RSV in children aged < 5 years in 7 European countries. We compare RSV-associated admission rates, age, seasonality, and time trends between countries.RESULTS: We found similar age distributions of RSV-associated hospital admissions in each country, with the highest burden in children < 1 years old and peak at age 1 month. Average annual rates of RTI admission were 41.3-112.0 per 1000 children aged < 1 year and 8.6-22.3 per 1000 children aged < 1 year. In children aged < 5 years, 57%-72% of RTI admissions with specified causal pathogen were coded as RSV, with 62%-87% of pathogen-coded admissions in children < 1 year coded as RSV.CONCLUSIONS: Our results demonstrate the benefits and limitations of using linked routinely collected data to explore epidemiology and burden of RSV. Our future work will use these data to generate estimates of RSV burden using time-series modelling methodology, to inform policymaking and regulatory decisions regarding RSV immunization strategy and monitor the impact of future vaccines.
AB - BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infection (RTI) in young children. Registries provide opportunities to explore RSV epidemiology and burden.METHODS: We explored routinely collected hospital data on RSV in children aged < 5 years in 7 European countries. We compare RSV-associated admission rates, age, seasonality, and time trends between countries.RESULTS: We found similar age distributions of RSV-associated hospital admissions in each country, with the highest burden in children < 1 years old and peak at age 1 month. Average annual rates of RTI admission were 41.3-112.0 per 1000 children aged < 1 year and 8.6-22.3 per 1000 children aged < 1 year. In children aged < 5 years, 57%-72% of RTI admissions with specified causal pathogen were coded as RSV, with 62%-87% of pathogen-coded admissions in children < 1 year coded as RSV.CONCLUSIONS: Our results demonstrate the benefits and limitations of using linked routinely collected data to explore epidemiology and burden of RSV. Our future work will use these data to generate estimates of RSV burden using time-series modelling methodology, to inform policymaking and regulatory decisions regarding RSV immunization strategy and monitor the impact of future vaccines.
KW - Europe
KW - hospital admissions
KW - national registry data
KW - respiratory syncytial virus
KW - RSV
UR - http://www.scopus.com/inward/record.url?scp=85092749580&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiaa360
DO - 10.1093/infdis/jiaa360
M3 - Journal article
C2 - 32815542
SN - 0022-1899
VL - 222
SP - S599-S605
JO - The Journal of infectious diseases
JF - The Journal of infectious diseases
IS - Supplement_7
ER -