Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects

Matthieu Allez; Konstantinos Karmiris; Edouard Louis; Gert Van Assche; Shomron Ben-Horin; Amir Klein; Janneke Van der Woude; Filip Baert; Rami Eliakim; Konstantinos Katsanos; Jørn Brynskov; Flavio Steinwurz; Silvio Danese; Severine Vermeire; Jean-Luc Teillaud; Marc Lémann; Yehuda Chowers

doi:10.1016/j.crohns.2010.04.004

Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects

Matthieu Allez, Konstantinos Karmiris, Edouard Louis, Gert Van Assche, Shomron Ben-Horin, Amir Klein, Janneke Van der Woude, Filip Baert, Rami Eliakim, Konstantinos Katsanos, Jørn Brynskov, Flavio Steinwurz, Silvio Danese, Severine Vermeire, Jean-Luc Teillaud, Marc Lémann, Yehuda Chowers

Mave-, Tarm- og Leversygdomme

304 Citationer (Scopus)

Abstract

The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory bowel diseases (IBDs). The overall objective was to better understand and explore primary non response and loss of response to anti-TNF agents in IBD. The outcome of this workshop is presented into two parts. This first section addresses definitions, frequency and pharmacological aspects of anti-TNF therapy failure, including pharmacokinetics of anti-TNF monoclonal antibodies and immune and non-immune mediated clearance of anti-TNF mAbs. The second section concerns the biological roles of TNF and TNF antagonists, including mechanisms of action of anti-TNF agents, and discuss hypothesis regarding their failures and phenomenon of paradoxical inflammation, including the potential role of TNF independent inflammatory pathways.

Originalsprog	Engelsk
Tidsskrift	Journal of Crohn's & colitis
Vol/bind	4
Udgave nummer	4
Sider (fra-til)	355-66
Antal sider	12
DOI	https://doi.org/10.1016/j.crohns.2010.04.004
Status	Udgivet - 1 okt. 2010

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10.1016/j.crohns.2010.04.004

Citationsformater

Allez, M., Karmiris, K., Louis, E., Van Assche, G., Ben-Horin, S., Klein, A., Van der Woude, J., Baert, F., Eliakim, R., Katsanos, K., Brynskov, J., Steinwurz, F., Danese, S., Vermeire, S., Teillaud, J.-L., Lémann, M., & Chowers, Y. (2010). Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects. Journal of Crohn's & colitis, 4(4), 355-66. https://doi.org/10.1016/j.crohns.2010.04.004

Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects. / Allez, Matthieu; Karmiris, Konstantinos; Louis, Edouard et al.
I: Journal of Crohn's & colitis, Bind 4, Nr. 4, 01.10.2010, s. 355-66.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Allez, M, Karmiris, K, Louis, E, Van Assche, G, Ben-Horin, S, Klein, A, Van der Woude, J, Baert, F, Eliakim, R, Katsanos, K, Brynskov, J, Steinwurz, F, Danese, S, Vermeire, S, Teillaud, J-L, Lémann, M & Chowers, Y 2010, 'Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects', Journal of Crohn's & colitis, bind 4, nr. 4, s. 355-66. https://doi.org/10.1016/j.crohns.2010.04.004

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Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects

Abstract

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