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Renal 123I-MIBG Uptake before and after Live-Donor Kidney Transplantation

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@article{a7e3a43e7835402395df43ddb99cb64c,
title = "Renal 123I-MIBG Uptake before and after Live-Donor Kidney Transplantation",
abstract = "Increased sympathetic activity is suggested to be part of the pathogenesis in several diseases. Methods to evaluate sympathetic activity and renal nervous denervation procedural success are lacking. Scintigraphy using the norepinephrine analog Iodine-123 Metaiodobenzylguanidine (123I-MIBG) might provide information on renal sympathetic nervous activity. Renal transplantation induces complete denervation of the kidney and as such represents an ideal model to evaluate the renal 123I-MIBG scintigraphy method. The aim of this study was to evaluate whether renal 123I-MIBG scintigraphy can detect changes in renal sympathetic nervous activity following renal transplantation. Renal 123I-MIBG scintigraphy was performed in eleven renal transplant recipients at 1, 3, and 6 months following transplantation and in their respective living donors prior to their kidney donation. Relative uptake as well as washout was obtained. In transplanted patients, the relative 4 h uptake of 123I-MIBG, as measured by the kidney/background ratio, was 2.7 (0.4) (mean (SD)), 2.7 (0.5), and 2.5 (0.4) at 1, 3, and 6 months post-transplantation, respectively, as compared with the 4.0 (0.4) value in the donor kidney before donor nephrectomy (p < 0.01). There was no significant change in washout-rate between pre-transplantation and any of the follow-up time points. Living donor kidney transplantation was at 6 months post transplantation, associated with an almost 40% reduction in the relative 4 h 123I-MIBG uptake of the kidney. Further studies will help to fully establish its implications as a marker of renal innervation or denervation.",
keywords = "I-MIBG scintigraphy, Live kidney donor, Renal nervous activity, Renal transplantation, Sympathetic nervous system, renal nervous activity, renal transplantation, sympathetic nervous system, live kidney donor, I-123-MIBG scintigraphy",
author = "Thomas Rasmussen and {de Nijs}, Robin and {Kj{\ae}r Olsen}, Lene and Anne-Lise Kamper and {Evi Bang}, Lia and Marie Frimodt-M{\o}ller and Henning Kelb{\ae}k and {Schwartz S{\o}rensen}, S{\o}ren and Andreas Kj{\ae}r and Bo Feldt-Rasmussen and {Hastrup Svendsen}, Jesper and Philip Hasbak",
year = "2020",
month = oct,
day = "9",
doi = "10.3390/diagnostics10100802",
language = "English",
volume = "10",
pages = "802",
journal = "Diagnostics",
issn = "2075-4418",
publisher = "M D P I AG",
number = "10",

}

RIS

TY - JOUR

T1 - Renal 123I-MIBG Uptake before and after Live-Donor Kidney Transplantation

AU - Rasmussen, Thomas

AU - de Nijs, Robin

AU - Kjær Olsen, Lene

AU - Kamper, Anne-Lise

AU - Evi Bang, Lia

AU - Frimodt-Møller, Marie

AU - Kelbæk, Henning

AU - Schwartz Sørensen, Søren

AU - Kjær, Andreas

AU - Feldt-Rasmussen, Bo

AU - Hastrup Svendsen, Jesper

AU - Hasbak, Philip

PY - 2020/10/9

Y1 - 2020/10/9

N2 - Increased sympathetic activity is suggested to be part of the pathogenesis in several diseases. Methods to evaluate sympathetic activity and renal nervous denervation procedural success are lacking. Scintigraphy using the norepinephrine analog Iodine-123 Metaiodobenzylguanidine (123I-MIBG) might provide information on renal sympathetic nervous activity. Renal transplantation induces complete denervation of the kidney and as such represents an ideal model to evaluate the renal 123I-MIBG scintigraphy method. The aim of this study was to evaluate whether renal 123I-MIBG scintigraphy can detect changes in renal sympathetic nervous activity following renal transplantation. Renal 123I-MIBG scintigraphy was performed in eleven renal transplant recipients at 1, 3, and 6 months following transplantation and in their respective living donors prior to their kidney donation. Relative uptake as well as washout was obtained. In transplanted patients, the relative 4 h uptake of 123I-MIBG, as measured by the kidney/background ratio, was 2.7 (0.4) (mean (SD)), 2.7 (0.5), and 2.5 (0.4) at 1, 3, and 6 months post-transplantation, respectively, as compared with the 4.0 (0.4) value in the donor kidney before donor nephrectomy (p < 0.01). There was no significant change in washout-rate between pre-transplantation and any of the follow-up time points. Living donor kidney transplantation was at 6 months post transplantation, associated with an almost 40% reduction in the relative 4 h 123I-MIBG uptake of the kidney. Further studies will help to fully establish its implications as a marker of renal innervation or denervation.

AB - Increased sympathetic activity is suggested to be part of the pathogenesis in several diseases. Methods to evaluate sympathetic activity and renal nervous denervation procedural success are lacking. Scintigraphy using the norepinephrine analog Iodine-123 Metaiodobenzylguanidine (123I-MIBG) might provide information on renal sympathetic nervous activity. Renal transplantation induces complete denervation of the kidney and as such represents an ideal model to evaluate the renal 123I-MIBG scintigraphy method. The aim of this study was to evaluate whether renal 123I-MIBG scintigraphy can detect changes in renal sympathetic nervous activity following renal transplantation. Renal 123I-MIBG scintigraphy was performed in eleven renal transplant recipients at 1, 3, and 6 months following transplantation and in their respective living donors prior to their kidney donation. Relative uptake as well as washout was obtained. In transplanted patients, the relative 4 h uptake of 123I-MIBG, as measured by the kidney/background ratio, was 2.7 (0.4) (mean (SD)), 2.7 (0.5), and 2.5 (0.4) at 1, 3, and 6 months post-transplantation, respectively, as compared with the 4.0 (0.4) value in the donor kidney before donor nephrectomy (p < 0.01). There was no significant change in washout-rate between pre-transplantation and any of the follow-up time points. Living donor kidney transplantation was at 6 months post transplantation, associated with an almost 40% reduction in the relative 4 h 123I-MIBG uptake of the kidney. Further studies will help to fully establish its implications as a marker of renal innervation or denervation.

KW - I-MIBG scintigraphy

KW - Live kidney donor

KW - Renal nervous activity

KW - Renal transplantation

KW - Sympathetic nervous system

KW - renal nervous activity

KW - renal transplantation

KW - sympathetic nervous system

KW - live kidney donor

KW - I-123-MIBG scintigraphy

UR - http://www.scopus.com/inward/record.url?scp=85092714064&partnerID=8YFLogxK

U2 - 10.3390/diagnostics10100802

DO - 10.3390/diagnostics10100802

M3 - Journal article

C2 - 33050245

VL - 10

SP - 802

JO - Diagnostics

JF - Diagnostics

SN - 2075-4418

IS - 10

M1 - 802

ER -

ID: 61111979