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Remodeling of muscle fibers approaching the human myotendinous junction

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@article{f8adb75855a9410db57e795fcfe4ce01,
title = "Remodeling of muscle fibers approaching the human myotendinous junction",
abstract = "The myotendinous junction (MTJ) is at high risk of strain injuries, due to high amounts of energy that is transferred through this structure. The risk of strain injury is significantly reduced by heavy resistance training (HRT), indicating a remodeling capacity of MTJ. We investigated the degree of remodeling of muscle fibers near the human MTJ. In 8 individuals, samples were taken from the semitendinosus and gracilis MTJ and they were stained immunohistochemically for myonuclei (DAPI), fibroblasts (TCF7L2), and satellite cells (CD56). A high portion of the muscle fibers adjacent to the MTJ contained a centrally located myonucleus (47 ± 8{\%}, mean ± SD) and half of the muscle fibers were CD56 positive. The number of satellite cells and fibroblasts were not higher than what has previously been reported from muscle bellies. The immunohistochemical findings suggest that the rate of remodeling of muscle fibers near the MTJ is very high. The finding that there was no increased number of satellite cells and fibroblasts could be explained as a dynamic phenomenon. The effect of HRT should be evaluated in a randomized setting.",
keywords = "Adult, CD56 Antigen/analysis, Cell Nucleus, Fibroblasts/cytology, Humans, Immunohistochemistry, Muscle Fibers, Skeletal/cytology, Resistance Training, Satellite Cells, Skeletal Muscle/cytology, Tendons/physiology",
author = "Jakobsen, {J R} and Jakobsen, {N R} and Mackey, {A L} and M Koch and Krogsgaard, {M R} and M Kjaer",
note = "{\circledC} 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2018",
month = "8",
doi = "10.1111/sms.13196",
language = "English",
volume = "28",
pages = "1859--1865",
journal = "Scandinavian Journal of Medicine and Science in Sports",
issn = "0905-7188",
publisher = "Wiley-Blackwell Munksgaard",
number = "8",

}

RIS

TY - JOUR

T1 - Remodeling of muscle fibers approaching the human myotendinous junction

AU - Jakobsen, J R

AU - Jakobsen, N R

AU - Mackey, A L

AU - Koch, M

AU - Krogsgaard, M R

AU - Kjaer, M

N1 - © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2018/8

Y1 - 2018/8

N2 - The myotendinous junction (MTJ) is at high risk of strain injuries, due to high amounts of energy that is transferred through this structure. The risk of strain injury is significantly reduced by heavy resistance training (HRT), indicating a remodeling capacity of MTJ. We investigated the degree of remodeling of muscle fibers near the human MTJ. In 8 individuals, samples were taken from the semitendinosus and gracilis MTJ and they were stained immunohistochemically for myonuclei (DAPI), fibroblasts (TCF7L2), and satellite cells (CD56). A high portion of the muscle fibers adjacent to the MTJ contained a centrally located myonucleus (47 ± 8%, mean ± SD) and half of the muscle fibers were CD56 positive. The number of satellite cells and fibroblasts were not higher than what has previously been reported from muscle bellies. The immunohistochemical findings suggest that the rate of remodeling of muscle fibers near the MTJ is very high. The finding that there was no increased number of satellite cells and fibroblasts could be explained as a dynamic phenomenon. The effect of HRT should be evaluated in a randomized setting.

AB - The myotendinous junction (MTJ) is at high risk of strain injuries, due to high amounts of energy that is transferred through this structure. The risk of strain injury is significantly reduced by heavy resistance training (HRT), indicating a remodeling capacity of MTJ. We investigated the degree of remodeling of muscle fibers near the human MTJ. In 8 individuals, samples were taken from the semitendinosus and gracilis MTJ and they were stained immunohistochemically for myonuclei (DAPI), fibroblasts (TCF7L2), and satellite cells (CD56). A high portion of the muscle fibers adjacent to the MTJ contained a centrally located myonucleus (47 ± 8%, mean ± SD) and half of the muscle fibers were CD56 positive. The number of satellite cells and fibroblasts were not higher than what has previously been reported from muscle bellies. The immunohistochemical findings suggest that the rate of remodeling of muscle fibers near the MTJ is very high. The finding that there was no increased number of satellite cells and fibroblasts could be explained as a dynamic phenomenon. The effect of HRT should be evaluated in a randomized setting.

KW - Adult

KW - CD56 Antigen/analysis

KW - Cell Nucleus

KW - Fibroblasts/cytology

KW - Humans

KW - Immunohistochemistry

KW - Muscle Fibers, Skeletal/cytology

KW - Resistance Training

KW - Satellite Cells, Skeletal Muscle/cytology

KW - Tendons/physiology

U2 - 10.1111/sms.13196

DO - 10.1111/sms.13196

M3 - Journal article

VL - 28

SP - 1859

EP - 1865

JO - Scandinavian Journal of Medicine and Science in Sports

JF - Scandinavian Journal of Medicine and Science in Sports

SN - 0905-7188

IS - 8

ER -

ID: 56334106