TY - JOUR
T1 - Remission and regression of diabetic nephropathy
AU - Hovind, Peter
AU - Tarnow, Lise
AU - Parving, Hans-Henrik
PY - 2004
Y1 - 2004
N2 - Diabetic kidney disease is considered to be an irreversible and inexorable progressive disease. Therefore, prevention of development of ESRD is extremely important. Animal studies have demonstrated that regression of existing renal morphologic lesions is feasible. In a sizable fraction of type 1 diabetic patients with overt nephropathy, remission (decrease in albuminuria to <300 mg/24 h) was obtained (31%), and regression of diabetic nephropathy (rate of decline in GFR < or = 1 mL/min/y), achieved (22%) by aggressive antihypertensive treatment. Furthermore, remission of nephrotic-range albuminuria (from >2500 mg/24 h to <600 mg/24 h) have been demonstrated to be achievable in one fifth of patients with nephrotic-range albuminuria. Remission of nephrotic-range albuminuria was associated with a reduction in decline in GFR and improved survival free of ESRD. However, to prevent development of ESRD in diabetic patients, an aggressive multifactorial approach, aiming at lowering blood pressure and albuminuria, and improving glycemic control, must be applied.
AB - Diabetic kidney disease is considered to be an irreversible and inexorable progressive disease. Therefore, prevention of development of ESRD is extremely important. Animal studies have demonstrated that regression of existing renal morphologic lesions is feasible. In a sizable fraction of type 1 diabetic patients with overt nephropathy, remission (decrease in albuminuria to <300 mg/24 h) was obtained (31%), and regression of diabetic nephropathy (rate of decline in GFR < or = 1 mL/min/y), achieved (22%) by aggressive antihypertensive treatment. Furthermore, remission of nephrotic-range albuminuria (from >2500 mg/24 h to <600 mg/24 h) have been demonstrated to be achievable in one fifth of patients with nephrotic-range albuminuria. Remission of nephrotic-range albuminuria was associated with a reduction in decline in GFR and improved survival free of ESRD. However, to prevent development of ESRD in diabetic patients, an aggressive multifactorial approach, aiming at lowering blood pressure and albuminuria, and improving glycemic control, must be applied.
KW - Albuminuria
KW - Animals
KW - Antihypertensive Agents
KW - Diabetes Mellitus, Type 1
KW - Diabetic Nephropathies
KW - Disease Progression
KW - Follow-Up Studies
KW - Glomerular Filtration Rate
KW - Humans
KW - Hypertension
KW - Kidney Failure, Chronic
KW - Kidney Function Tests
KW - Primary Prevention
KW - Randomized Controlled Trials as Topic
KW - Remission, Spontaneous
KW - Risk Assessment
KW - Severity of Illness Index
KW - Treatment Outcome
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Review
M3 - Journal article
C2 - 15341691
SN - 1522-6417
VL - 6
SP - 377
EP - 382
JO - Current Hypertension Reports
JF - Current Hypertension Reports
IS - 5
ER -