TY - JOUR
T1 - Relaxation enhancing properties of MnDPDP in human myocardium
AU - Skjold, Arne
AU - Vangberg, Torgil R
AU - Kristoffersen, Anders
AU - Haraldseth, Olav
AU - Jynge, Per
AU - Larsson, Henrik B W
N1 - 2004 Wiley-Liss, Inc.
PY - 2004/12
Y1 - 2004/12
N2 - PURPOSE: To assess magnitude and duration of changes in myocardial longitudinal relaxation rate (R1) in humans following infusion of the manganese (Mn) releasing contrast agent MnDPDP (Mn-dipyridoxyl-diphosphate).MATERIALS AND METHODS: Fifteen healthy volunteers were divided into three groups. After initial myocardial and liver R1 measurements using an inversion recovery (IR) turbo fast low-angle shot (FLASH) sequence at 1.5 Tesla, the groups were given different doses of intravenous MnDPDP: 5, 10 and 15 micromol/kg body weight, respectively, over 30 minutes. R1 measurements were then repeated at 1, 2, 4, 8, and 24 hours after the infusion ended.RESULTS: The left ventricular wall R1 prevalue was 0.98 second(-1) (+/-0.04). R1 increased on average (all 15 subjects) 0.41 second(-1) (+/-0.09). The increase was present one hour after the end of the infusion, remained relatively constant the next two hours, and then declined gradually. After 24 hours, there was still a moderate R1 elevation present, with an average R1-value of 1.16 (+/-0.05). There were only small differences in myocardial R1 responses between the three doses investigated, which was contrasted by a marked dose-response in liver tissue.CONCLUSION: MnDPDP gave a significant and prolonged rise in myocardial R1 even at a dose of 5 micromol/kg. The R1-values in the myocardium did not increase linearly with higher doses.
AB - PURPOSE: To assess magnitude and duration of changes in myocardial longitudinal relaxation rate (R1) in humans following infusion of the manganese (Mn) releasing contrast agent MnDPDP (Mn-dipyridoxyl-diphosphate).MATERIALS AND METHODS: Fifteen healthy volunteers were divided into three groups. After initial myocardial and liver R1 measurements using an inversion recovery (IR) turbo fast low-angle shot (FLASH) sequence at 1.5 Tesla, the groups were given different doses of intravenous MnDPDP: 5, 10 and 15 micromol/kg body weight, respectively, over 30 minutes. R1 measurements were then repeated at 1, 2, 4, 8, and 24 hours after the infusion ended.RESULTS: The left ventricular wall R1 prevalue was 0.98 second(-1) (+/-0.04). R1 increased on average (all 15 subjects) 0.41 second(-1) (+/-0.09). The increase was present one hour after the end of the infusion, remained relatively constant the next two hours, and then declined gradually. After 24 hours, there was still a moderate R1 elevation present, with an average R1-value of 1.16 (+/-0.05). There were only small differences in myocardial R1 responses between the three doses investigated, which was contrasted by a marked dose-response in liver tissue.CONCLUSION: MnDPDP gave a significant and prolonged rise in myocardial R1 even at a dose of 5 micromol/kg. The R1-values in the myocardium did not increase linearly with higher doses.
KW - Adult
KW - Contrast Media/administration & dosage
KW - Dose-Response Relationship, Drug
KW - Edetic Acid/administration & dosage
KW - Electrocardiography
KW - Female
KW - Heart Rate
KW - Humans
KW - Liver/metabolism
KW - Magnetic Resonance Imaging
KW - Male
KW - Manganese/pharmacokinetics
KW - Myocardial Contraction/drug effects
KW - Myocardium/metabolism
KW - Pyridoxal Phosphate/administration & dosage
U2 - 10.1002/jmri.20200
DO - 10.1002/jmri.20200
M3 - Journal article
C2 - 15558550
SN - 1053-1807
VL - 20
SP - 948
EP - 952
JO - Journal of magnetic resonance imaging : JMRI
JF - Journal of magnetic resonance imaging : JMRI
IS - 6
ER -