Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration: a MACUSTAR study report

Marlene Saßmannshausen; Charlotte Behning; Ben Isselmann; Matthias Schmid; Robert P. Finger; F. G. Holz; Steffen Schmitz-Valckenberg; Maximilian Pfau; H. Agostini; L. Altay; R. Atia; F. Bandello; P. G. Basile; C. Behning; M. Berger; A. Binns; C. J.F. Boon; M. Böttger; C. Bouchet; J. E. Brazier; T. Butt; C. Carapezzi; J. Carlton; A. Carneiro; A. Charil; R. Coimbra; M. Cozzi; D. P. Crabb; J. Cunha-Vaz; C. Dahlke; L. de Sisternes; H. Dunbar; R. P. Finger; E. Fletcher; H. Floyd; C. Francisco; M. Gutfleisch; R. Hogg; F. G. Holz; C. B. Hoyng; A. Kilani; J. Krätzschmar; L. Kühlewein; S. Leal; Y. T.E. Lechanteur; U. F.O. Luhmann; A. Lüning; I. Marques; MACUSTAR Consortium; M. Belmouhand; M. Larsen

doi:10.1038/s41598-022-18875-5

Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration: a MACUSTAR study report

Marlene Saßmannshausen, Charlotte Behning, Ben Isselmann, Matthias Schmid, Robert P. Finger, F. G. Holz, Steffen Schmitz-Valckenberg, Maximilian Pfau, H. Agostini, L. Altay, R. Atia, F. Bandello, P. G. Basile, C. Behning, M. Berger, A. Binns, C. J.F. Boon, M. Böttger, C. Bouchet, J. E. BrazierT. Butt, C. Carapezzi, J. Carlton, A. Carneiro, A. Charil, R. Coimbra, M. Cozzi, D. P. Crabb, J. Cunha-Vaz, C. Dahlke, L. de Sisternes, H. Dunbar, R. P. Finger, E. Fletcher, H. Floyd, C. Francisco, M. Gutfleisch, R. Hogg, F. G. Holz, C. B. Hoyng, A. Kilani, J. Krätzschmar, L. Kühlewein, S. Leal, Y. T.E. Lechanteur, U. F.O. Luhmann, A. Lüning, I. Marques, MACUSTAR Consortium, M. Belmouhand (Medlem af forfattergruppering), M. Larsen (Medlem af forfattergruppering)

Afdeling for Øjensygdomme

15 Citationer (Scopus)

Abstract

Quantification of the relative ellipsoid zone reflectivity (rEZR) might be a structural surrogate parameter for an early disease progression in the context of age-related macular degeneration (AMD). Within the European multicenter, cross-sectional MACUSTAR study, we have devised an automatic approach to determine the mean rEZR [arbitrary units, AU] at two independent visits in SD-OCT volume scans in study participants. Linear mixed-effects models were applied to analyze the association of AMD stage and AMD associated high-risk features including presence of pigmentary abnormalities, reticular pseudodrusen (RPD), volume of the retinal-pigment-epithelial-drusenoid-complex (RPEDC) with the rEZR. Intra-class correlation coefficients (ICC) were determined for rEZR reliability analysis. Within the overall study cohort (301 participants), we could observe decreased rEZR values (coefficient estimate ± standard error) of - 8.05 ± 2.44 AU (p = 0.0011) in the intermediate and of - 22.35 ± 3.28 AU (p < 0.0001) in the late AMD group. RPD presence was significantly associated with the rEZR in iAMD eyes (- 6.49 ± 3.14 AU; p = 0.0403), while there was a good ICC of 0.846 (95% confidence interval: 0.809; 0.876) in the overall study cohort. This study showed an association of rEZR with increasing disease severity and the presence of iAMD high-risk features. Further studies are necessary to evaluate the rEZR's value as a novel biomarker for AMD and disease progression.

Originalsprog	Engelsk
Artikelnummer	14933
Tidsskrift	Scientific Reports
Vol/bind	12
Udgave nummer	1
ISSN	2045-2322
DOI	https://doi.org/10.1038/s41598-022-18875-5
Status	Udgivet - dec. 2022

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Saßmannshausen, M., Behning, C., Isselmann, B., Schmid, M., Finger, R. P., Holz, F. G., Schmitz-Valckenberg, S., Pfau, M., Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Behning, C., Berger, M., Binns, A., Boon, C. J. F., Böttger, M., Bouchet, C., ... Larsen, M. (2022). Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration: a MACUSTAR study report. Scientific Reports, 12(1), Artikel 14933. https://doi.org/10.1038/s41598-022-18875-5

Saßmannshausen, M, Behning, C, Isselmann, B, Schmid, M, Finger, RP, Holz, FG, Schmitz-Valckenberg, S, Pfau, M, Agostini, H, Altay, L, Atia, R, Bandello, F, Basile, PG, Behning, C, Berger, M, Binns, A, Boon, CJF, Böttger, M, Bouchet, C, Brazier, JE, Butt, T, Carapezzi, C, Carlton, J, Carneiro, A, Charil, A, Coimbra, R, Cozzi, M, Crabb, DP, Cunha-Vaz, J, Dahlke, C, de Sisternes, L, Dunbar, H, Finger, RP, Fletcher, E, Floyd, H, Francisco, C, Gutfleisch, M, Hogg, R, Holz, FG, Hoyng, CB, Kilani, A, Krätzschmar, J, Kühlewein, L, Leal, S, Lechanteur, YTE, Luhmann, UFO, Lüning, A, Marques, I, MACUSTAR Consortium, Belmouhand, M & Larsen, M 2022, 'Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration: a MACUSTAR study report', Scientific Reports, bind 12, nr. 1, 14933. https://doi.org/10.1038/s41598-022-18875-5

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title = "Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration: a MACUSTAR study report",

abstract = "Quantification of the relative ellipsoid zone reflectivity (rEZR) might be a structural surrogate parameter for an early disease progression in the context of age-related macular degeneration (AMD). Within the European multicenter, cross-sectional MACUSTAR study, we have devised an automatic approach to determine the mean rEZR [arbitrary units, AU] at two independent visits in SD-OCT volume scans in study participants. Linear mixed-effects models were applied to analyze the association of AMD stage and AMD associated high-risk features including presence of pigmentary abnormalities, reticular pseudodrusen (RPD), volume of the retinal-pigment-epithelial-drusenoid-complex (RPEDC) with the rEZR. Intra-class correlation coefficients (ICC) were determined for rEZR reliability analysis. Within the overall study cohort (301 participants), we could observe decreased rEZR values (coefficient estimate ± standard error) of - 8.05 ± 2.44 AU (p = 0.0011) in the intermediate and of - 22.35 ± 3.28 AU (p < 0.0001) in the late AMD group. RPD presence was significantly associated with the rEZR in iAMD eyes (- 6.49 ± 3.14 AU; p = 0.0403), while there was a good ICC of 0.846 (95% confidence interval: 0.809; 0.876) in the overall study cohort. This study showed an association of rEZR with increasing disease severity and the presence of iAMD high-risk features. Further studies are necessary to evaluate the rEZR's value as a novel biomarker for AMD and disease progression.",

author = "Marlene Sa{\ss}mannshausen and Charlotte Behning and Ben Isselmann and Matthias Schmid and Finger, {Robert P.} and Holz, {F. G.} and Steffen Schmitz-Valckenberg and Maximilian Pfau and H. Agostini and L. Altay and R. Atia and F. Bandello and Basile, {P. G.} and C. Behning and M. Berger and A. Binns and Boon, {C. J.F.} and M. B{\"o}ttger and C. Bouchet and Brazier, {J. E.} and T. Butt and C. Carapezzi and J. Carlton and A. Carneiro and A. Charil and R. Coimbra and M. Cozzi and Crabb, {D. P.} and J. Cunha-Vaz and C. Dahlke and {de Sisternes}, L. and H. Dunbar and Finger, {R. P.} and E. Fletcher and H. Floyd and C. Francisco and M. Gutfleisch and R. Hogg and Holz, {F. G.} and Hoyng, {C. B.} and A. Kilani and J. Kr{\"a}tzschmar and L. K{\"u}hlewein and S. Leal and Lechanteur, {Y. T.E.} and Luhmann, {U. F.O.} and A. L{\"u}ning and I. Marques and {MACUSTAR Consortium} and M. Belmouhand and M. Larsen",

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year = "2022",

month = dec,

doi = "10.1038/s41598-022-18875-5",

language = "English",

volume = "12",

journal = "Scientific Reports",

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T1 - Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration

T2 - a MACUSTAR study report

AU - Saßmannshausen, Marlene

AU - Behning, Charlotte

AU - Isselmann, Ben

AU - Schmid, Matthias

AU - Finger, Robert P.

AU - Holz, F. G.

AU - Schmitz-Valckenberg, Steffen

AU - Pfau, Maximilian

AU - Agostini, H.

AU - Altay, L.

AU - Atia, R.

AU - Bandello, F.

AU - Basile, P. G.

AU - Behning, C.

AU - Berger, M.

AU - Binns, A.

AU - Boon, C. J.F.

AU - Böttger, M.

AU - Bouchet, C.

AU - Brazier, J. E.

AU - Butt, T.

AU - Carapezzi, C.

AU - Carlton, J.

AU - Carneiro, A.

AU - Charil, A.

AU - Coimbra, R.

AU - Cozzi, M.

AU - Crabb, D. P.

AU - Cunha-Vaz, J.

AU - Dahlke, C.

AU - de Sisternes, L.

AU - Dunbar, H.

AU - Finger, R. P.

AU - Fletcher, E.

AU - Floyd, H.

AU - Francisco, C.

AU - Gutfleisch, M.

AU - Hogg, R.

AU - Holz, F. G.

AU - Hoyng, C. B.

AU - Kilani, A.

AU - Krätzschmar, J.

AU - Kühlewein, L.

AU - Leal, S.

AU - Lechanteur, Y. T.E.

AU - Luhmann, U. F.O.

AU - Lüning, A.

AU - Marques, I.

AU - MACUSTAR Consortium

A2 - Belmouhand, M.

A2 - Larsen, M.

PY - 2022/12

Y1 - 2022/12

N2 - Quantification of the relative ellipsoid zone reflectivity (rEZR) might be a structural surrogate parameter for an early disease progression in the context of age-related macular degeneration (AMD). Within the European multicenter, cross-sectional MACUSTAR study, we have devised an automatic approach to determine the mean rEZR [arbitrary units, AU] at two independent visits in SD-OCT volume scans in study participants. Linear mixed-effects models were applied to analyze the association of AMD stage and AMD associated high-risk features including presence of pigmentary abnormalities, reticular pseudodrusen (RPD), volume of the retinal-pigment-epithelial-drusenoid-complex (RPEDC) with the rEZR. Intra-class correlation coefficients (ICC) were determined for rEZR reliability analysis. Within the overall study cohort (301 participants), we could observe decreased rEZR values (coefficient estimate ± standard error) of - 8.05 ± 2.44 AU (p = 0.0011) in the intermediate and of - 22.35 ± 3.28 AU (p < 0.0001) in the late AMD group. RPD presence was significantly associated with the rEZR in iAMD eyes (- 6.49 ± 3.14 AU; p = 0.0403), while there was a good ICC of 0.846 (95% confidence interval: 0.809; 0.876) in the overall study cohort. This study showed an association of rEZR with increasing disease severity and the presence of iAMD high-risk features. Further studies are necessary to evaluate the rEZR's value as a novel biomarker for AMD and disease progression.

AB - Quantification of the relative ellipsoid zone reflectivity (rEZR) might be a structural surrogate parameter for an early disease progression in the context of age-related macular degeneration (AMD). Within the European multicenter, cross-sectional MACUSTAR study, we have devised an automatic approach to determine the mean rEZR [arbitrary units, AU] at two independent visits in SD-OCT volume scans in study participants. Linear mixed-effects models were applied to analyze the association of AMD stage and AMD associated high-risk features including presence of pigmentary abnormalities, reticular pseudodrusen (RPD), volume of the retinal-pigment-epithelial-drusenoid-complex (RPEDC) with the rEZR. Intra-class correlation coefficients (ICC) were determined for rEZR reliability analysis. Within the overall study cohort (301 participants), we could observe decreased rEZR values (coefficient estimate ± standard error) of - 8.05 ± 2.44 AU (p = 0.0011) in the intermediate and of - 22.35 ± 3.28 AU (p < 0.0001) in the late AMD group. RPD presence was significantly associated with the rEZR in iAMD eyes (- 6.49 ± 3.14 AU; p = 0.0403), while there was a good ICC of 0.846 (95% confidence interval: 0.809; 0.876) in the overall study cohort. This study showed an association of rEZR with increasing disease severity and the presence of iAMD high-risk features. Further studies are necessary to evaluate the rEZR's value as a novel biomarker for AMD and disease progression.

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Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration: a MACUSTAR study report

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