Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Relationship between left atrial strain, diastolic dysfunction and subclinical atrial fibrillation in patients with cryptogenic stroke: the SURPRISE echo substudy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Cardiovascular comorbidities as predictors for severe COVID-19 infection or death

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Association between the E-wave propagation index and left ventricular thrombus formation after ST-elevation myocardial infarction

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Right atrial strain: Tapping into a new reservoir of hemodynamic information

    Publikation: Bidrag til tidsskriftLederpeer review

  4. Prognostic factors of 90-day mortality in patients hospitalised with COVID-19

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Atrial fibrillation is a marker of increased mortality risk in non-ischemic heart failure - results from the DANISH Trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Paroxysmal atrial fibrillation (PAF) may be the cause of a substantial part of cryptogenic strokes (CS). Echocardiography could assist risk stratification for PAF to select patients in need of prolonged rhythm monitoring. We aimed to assess the value of left atrial (LA) strain and a revised diastolic dysfunction (DDF) model with LA strain for predicting PAF. This was a prospective study of 56 CS patients who had a cardiac monitor implanted for 3 year monitoring for PAF, and an echocardiogram performed prior to monitoring. Conventional echocardiography, global longitudinal strain (GLS) and LA strain were performed. LA speckle tracking provided the LA reservoir strain (LAs). Patients were stratified into high versus low LAs by ROC curves (28.2%), and this cut-off was used to refine DDF grading. During follow-up of median 20 months, 13 (23%) patients were diagnosed with PAF. No conventional echocardiographic parameters differed between patients who developed PAF and those without PAF. However, LAs was significantly impaired in PAF patients (LAs: 30 vs. 27% for non-PAF and PAF, p = 0.046). Low LAs significantly predicted PAF independent of LA volume and GLS [OR 5.88 (1.30; 26.55), p = 0.021]. Revised DDF grading significantly predicted PAF, even when adjusted for the CHADS2 risk-score (OR 1.88 [1.01;3.50], per increase in DDF grade, p for trend = 0.047), which was not the case for conventional DDF grading. In conclusion, LAs associates with PAF independent of GLS and LA size, and may be used to improve the performance of DDF grading for identifying PAF in CS patients.

TidsskriftThe international journal of cardiovascular imaging
Udgave nummer1
Sider (fra-til)79-89
Antal sider11
StatusUdgivet - 1 jan. 2020

ID: 58954530