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Relationship between heart rate and outcomes in patients in sinus rhythm or atrial fibrillation with heart failure and reduced ejection fraction

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Docherty, KF, Shen, L, Castagno, D, Petrie, MC, Abraham, WT, Böhm, M, Desai, AS, Dickstein, K, Køber, LV, Packer, M, Rouleau, JL, Solomon, SD, Swedberg, K, Vazir, A, Zile, MR, Jhund, PS & McMurray, JJV 2020, 'Relationship between heart rate and outcomes in patients in sinus rhythm or atrial fibrillation with heart failure and reduced ejection fraction' European Journal of Heart Failure, bind 22, nr. 3, s. 528-538. https://doi.org/10.1002/ejhf.1682

APA

CBE

Docherty KF, Shen L, Castagno D, Petrie MC, Abraham WT, Böhm M, Desai AS, Dickstein K, Køber LV, Packer M, Rouleau JL, Solomon SD, Swedberg K, Vazir A, Zile MR, Jhund PS, McMurray JJV. 2020. Relationship between heart rate and outcomes in patients in sinus rhythm or atrial fibrillation with heart failure and reduced ejection fraction. European Journal of Heart Failure. 22(3):528-538. https://doi.org/10.1002/ejhf.1682

MLA

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Author

Docherty, Kieran F ; Shen, Li ; Castagno, Davide ; Petrie, Mark C ; Abraham, William T ; Böhm, Michael ; Desai, Akshay S ; Dickstein, Kenneth ; Køber, Lars V ; Packer, Milton ; Rouleau, Jean L ; Solomon, Scott D ; Swedberg, Karl ; Vazir, Ali ; Zile, Michael R ; Jhund, Pardeep S ; McMurray, John J V. / Relationship between heart rate and outcomes in patients in sinus rhythm or atrial fibrillation with heart failure and reduced ejection fraction. I: European Journal of Heart Failure. 2020 ; Bind 22, Nr. 3. s. 528-538.

Bibtex

@article{4b0775dbad0b4ac9b7d1040579c1f4d4,
title = "Relationship between heart rate and outcomes in patients in sinus rhythm or atrial fibrillation with heart failure and reduced ejection fraction",
abstract = "AIMS: To investigate the relationship between heart rate and outcomes in heart failure and reduced ejection fraction (HFrEF) patients in sinus rhythm (SR) and atrial fibrillation (AF) adjusting for natriuretic peptide concentration, a powerful prognosticator.METHODS AND RESULTS: Of 13 562 patients from two large HFrEF trials, 10 113 (74.6{\%}) were in SR and 3449 (25.4{\%}) in AF. The primary endpoint was the composite of cardiovascular death or heart failure hospitalization. Heart rate was analysed as a categorical (tertiles, T1-3) and continuous variable (per 10 bpm), separately in patients in SR and AF. Outcomes were adjusted for prognostic variables, including N-terminal prohormone of B-type natriuretic peptide (NT-proBNP), and also examined using change from baseline heart rate to 1 year (≤ -10 bpm, ≥ +10 bpm, < ±10 bpm). SR patients with a higher heart rate had worse symptoms and quality of life, more often had diabetes and higher NT-proBNP concentrations. They had higher risk of the primary endpoint [T3 vs. T1 adjusted hazard ratio (HR) 1.50, 95{\%} confidence interval (CI) 1.35-1.66; P < 0.001; per 10 bpm: 1.12, 95{\%} CI 1.09-1.16; P < 0.001]. In SR, heart rate was associated with a relatively higher risk of pump failure than sudden death (adjusted HR per 10 bpm 1.17, 95{\%} CI 1.09-1.26; P < 0.001 vs. 1.07, 95{\%} CI 1.02-1.13; P = 0.011). Heart rate was not predictive of any outcome in AF.CONCLUSIONS: In HFrEF, an elevated heart rate was an independent predictor of adverse cardiovascular outcomes in patients in SR, even after adjustment for NT-proBNP. There was no relationship between heart rate and outcomes in AF.CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov Identifiers NCT01035255 and NCT00853658.",
author = "Docherty, {Kieran F} and Li Shen and Davide Castagno and Petrie, {Mark C} and Abraham, {William T} and Michael B{\"o}hm and Desai, {Akshay S} and Kenneth Dickstein and K{\o}ber, {Lars V} and Milton Packer and Rouleau, {Jean L} and Solomon, {Scott D} and Karl Swedberg and Ali Vazir and Zile, {Michael R} and Jhund, {Pardeep S} and McMurray, {John J V}",
note = "{\circledC} 2019 European Society of Cardiology.",
year = "2020",
month = "3",
doi = "10.1002/ejhf.1682",
language = "English",
volume = "22",
pages = "528--538",
journal = "European Journal of Heart Failure",
issn = "1388-9842",
publisher = "Wiley",
number = "3",

}

RIS

TY - JOUR

T1 - Relationship between heart rate and outcomes in patients in sinus rhythm or atrial fibrillation with heart failure and reduced ejection fraction

AU - Docherty, Kieran F

AU - Shen, Li

AU - Castagno, Davide

AU - Petrie, Mark C

AU - Abraham, William T

AU - Böhm, Michael

AU - Desai, Akshay S

AU - Dickstein, Kenneth

AU - Køber, Lars V

AU - Packer, Milton

AU - Rouleau, Jean L

AU - Solomon, Scott D

AU - Swedberg, Karl

AU - Vazir, Ali

AU - Zile, Michael R

AU - Jhund, Pardeep S

AU - McMurray, John J V

N1 - © 2019 European Society of Cardiology.

PY - 2020/3

Y1 - 2020/3

N2 - AIMS: To investigate the relationship between heart rate and outcomes in heart failure and reduced ejection fraction (HFrEF) patients in sinus rhythm (SR) and atrial fibrillation (AF) adjusting for natriuretic peptide concentration, a powerful prognosticator.METHODS AND RESULTS: Of 13 562 patients from two large HFrEF trials, 10 113 (74.6%) were in SR and 3449 (25.4%) in AF. The primary endpoint was the composite of cardiovascular death or heart failure hospitalization. Heart rate was analysed as a categorical (tertiles, T1-3) and continuous variable (per 10 bpm), separately in patients in SR and AF. Outcomes were adjusted for prognostic variables, including N-terminal prohormone of B-type natriuretic peptide (NT-proBNP), and also examined using change from baseline heart rate to 1 year (≤ -10 bpm, ≥ +10 bpm, < ±10 bpm). SR patients with a higher heart rate had worse symptoms and quality of life, more often had diabetes and higher NT-proBNP concentrations. They had higher risk of the primary endpoint [T3 vs. T1 adjusted hazard ratio (HR) 1.50, 95% confidence interval (CI) 1.35-1.66; P < 0.001; per 10 bpm: 1.12, 95% CI 1.09-1.16; P < 0.001]. In SR, heart rate was associated with a relatively higher risk of pump failure than sudden death (adjusted HR per 10 bpm 1.17, 95% CI 1.09-1.26; P < 0.001 vs. 1.07, 95% CI 1.02-1.13; P = 0.011). Heart rate was not predictive of any outcome in AF.CONCLUSIONS: In HFrEF, an elevated heart rate was an independent predictor of adverse cardiovascular outcomes in patients in SR, even after adjustment for NT-proBNP. There was no relationship between heart rate and outcomes in AF.CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov Identifiers NCT01035255 and NCT00853658.

AB - AIMS: To investigate the relationship between heart rate and outcomes in heart failure and reduced ejection fraction (HFrEF) patients in sinus rhythm (SR) and atrial fibrillation (AF) adjusting for natriuretic peptide concentration, a powerful prognosticator.METHODS AND RESULTS: Of 13 562 patients from two large HFrEF trials, 10 113 (74.6%) were in SR and 3449 (25.4%) in AF. The primary endpoint was the composite of cardiovascular death or heart failure hospitalization. Heart rate was analysed as a categorical (tertiles, T1-3) and continuous variable (per 10 bpm), separately in patients in SR and AF. Outcomes were adjusted for prognostic variables, including N-terminal prohormone of B-type natriuretic peptide (NT-proBNP), and also examined using change from baseline heart rate to 1 year (≤ -10 bpm, ≥ +10 bpm, < ±10 bpm). SR patients with a higher heart rate had worse symptoms and quality of life, more often had diabetes and higher NT-proBNP concentrations. They had higher risk of the primary endpoint [T3 vs. T1 adjusted hazard ratio (HR) 1.50, 95% confidence interval (CI) 1.35-1.66; P < 0.001; per 10 bpm: 1.12, 95% CI 1.09-1.16; P < 0.001]. In SR, heart rate was associated with a relatively higher risk of pump failure than sudden death (adjusted HR per 10 bpm 1.17, 95% CI 1.09-1.26; P < 0.001 vs. 1.07, 95% CI 1.02-1.13; P = 0.011). Heart rate was not predictive of any outcome in AF.CONCLUSIONS: In HFrEF, an elevated heart rate was an independent predictor of adverse cardiovascular outcomes in patients in SR, even after adjustment for NT-proBNP. There was no relationship between heart rate and outcomes in AF.CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov Identifiers NCT01035255 and NCT00853658.

U2 - 10.1002/ejhf.1682

DO - 10.1002/ejhf.1682

M3 - Journal article

VL - 22

SP - 528

EP - 538

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1388-9842

IS - 3

ER -

ID: 59437662