TY - JOUR
T1 - Relationship between Diabetic Retinopathy and Primary Open-Angle Glaucoma
T2 - A Systematic Review and Meta-Analysis
AU - Kjærsgaard, Marianne
AU - Grauslund, Jakob
AU - Vestergaard, Anders Højslet
AU - Subhi, Yousif
N1 - Publisher Copyright:
© 2022 The Author(s). Published by S. Karger AG, Basel.
PY - 2022/8/21
Y1 - 2022/8/21
N2 - Background: Pathophysiological overlaps exist between diabetes and primary open-angle glaucoma (POAG) and presence of diabetes increases the risk of POAG. Considering that diabetic retinopathy (DR) is an ocular complication of diabetes, one could speculate that DR as a severity measure may associate with or even predict POAG. Given that POAG is asymptomatic in early stages, an association to DR may prove clinically important and facilitate an earlier diagnosis of POAG. Objectives: The aim of the study was to investigate if DR is associated with and predictive of POAG. Method: We systematically searched 11 literature databases on May 12, 2021. We screened a total of 1,535 records and found six studies eligible for qualitative and quantitative analysis. Two independent authors reviewed the studies, extracted data, and evaluated risk of bias within individual studies. Studies were reviewed qualitatively, and meta-analyses were made based on the odds ratios (ORs) with 95% confidence intervals (CI) of the association between DR and POAG using the random-effects model. Subgroup analyses were made on the association between subtypes of DR and POAG. Results: Six studies (two longitudinal and four cross-sectional) were eligible for review with a total of 255,614 patients with diabetes, of which 20,483 patients had any degree of DR and 5,258 had POAG. All studies were based on patients with type 2 diabetes except one with both type 1 and type 2 patients. Any DR was not associated with POAG (OR 1.17; 95% CI: 0.58-2.35; p = 0.65). Further stratification revealed that neither cross-sectional (OR 1.00; 95% CI: 0.56-1.81, p = 0.99) nor longitudinal studies (OR 1.47; 95% CI: 0.57-3.78, p = 0.43) demonstrated an association between DR and POAG. Conclusions: We did not find convincing evidence of an associations between DR and prevalent or incident POAG.
AB - Background: Pathophysiological overlaps exist between diabetes and primary open-angle glaucoma (POAG) and presence of diabetes increases the risk of POAG. Considering that diabetic retinopathy (DR) is an ocular complication of diabetes, one could speculate that DR as a severity measure may associate with or even predict POAG. Given that POAG is asymptomatic in early stages, an association to DR may prove clinically important and facilitate an earlier diagnosis of POAG. Objectives: The aim of the study was to investigate if DR is associated with and predictive of POAG. Method: We systematically searched 11 literature databases on May 12, 2021. We screened a total of 1,535 records and found six studies eligible for qualitative and quantitative analysis. Two independent authors reviewed the studies, extracted data, and evaluated risk of bias within individual studies. Studies were reviewed qualitatively, and meta-analyses were made based on the odds ratios (ORs) with 95% confidence intervals (CI) of the association between DR and POAG using the random-effects model. Subgroup analyses were made on the association between subtypes of DR and POAG. Results: Six studies (two longitudinal and four cross-sectional) were eligible for review with a total of 255,614 patients with diabetes, of which 20,483 patients had any degree of DR and 5,258 had POAG. All studies were based on patients with type 2 diabetes except one with both type 1 and type 2 patients. Any DR was not associated with POAG (OR 1.17; 95% CI: 0.58-2.35; p = 0.65). Further stratification revealed that neither cross-sectional (OR 1.00; 95% CI: 0.56-1.81, p = 0.99) nor longitudinal studies (OR 1.47; 95% CI: 0.57-3.78, p = 0.43) demonstrated an association between DR and POAG. Conclusions: We did not find convincing evidence of an associations between DR and prevalent or incident POAG.
KW - Diabetic retinopathy
KW - Meta-analysis
KW - Primary open-angle glaucoma
KW - Systematic review
KW - Cross-Sectional Studies
KW - Humans
KW - Glaucoma, Open-Angle/complications
KW - Diabetes Mellitus, Type 2/complications
KW - Diabetic Retinopathy/complications
KW - Polymorphism, Genetic
UR - http://www.scopus.com/inward/record.url?scp=85135597857&partnerID=8YFLogxK
U2 - 10.1159/000523940
DO - 10.1159/000523940
M3 - Review
C2 - 35313300
AN - SCOPUS:85135597857
SN - 0030-3747
VL - 65
SP - 377
EP - 386
JO - Ophthalmic Research
JF - Ophthalmic Research
IS - 4
ER -