Reintervention and Survival After Transcatheter Pulmonary Valve Replacement

Doff B McElhinney, Yulin Zhang, Daniel S Levi, Stanimir Georgiev, Elżbieta Katarzyna Biernacka, Bryan H Goldstein, Shabana Shahanavaz, Athar M Qureshi, Allison K Cabalka, Holly Bauser-Heaton, Alejandro J Torres, Brian H Morray, Aimee K Armstrong, Oscar Millan-Iturbe, Lynn F Peng, Jamil A Aboulhosn, Witold Rużyłło, Felix Berger, Lars Sondergaard, Dietmar SchranzJohn P Cheatham, Thomas K Jones, Peter Ewert, Stephan Schubert

Abstract

BACKGROUND: Transcatheter pulmonary valve (TPV) replacement (TPVR) has become the standard therapy for postoperative pulmonary outflow tract dysfunction in patients with a prosthetic conduit/valve, but there is limited information about risk factors for death or reintervention after this procedure.

OBJECTIVES: This study sought to evaluate mid- and long-term outcomes after TPVR in a large multicenter cohort.

METHODS: International registry focused on time-related outcomes after TPVR.

RESULTS: Investigators submitted data for 2,476 patients who underwent TPVR and were followed up for 8,475 patient-years. A total of 95 patients died after TPVR, most commonly from heart failure (n = 24). The cumulative incidence of death was 8.9% (95% CI: 6.9%-11.5%) 8 years after TPVR. On multivariable analysis, age at TPVR (HR: 1.04 per year; 95% CI: 1.03-1.06 per year; P < 0.001), a prosthetic valve in other positions (HR: 2.1; 95% CI: 1.2-3.7; P = 0.014), and an existing transvenous pacemaker/implantable cardioverter-defibrillator (HR: 2.1; 95% CI: 1.3-3.4; P = 0.004) were associated with death. A total of 258 patients underwent TPV reintervention. At 8 years, the cumulative incidence of any TPV reintervention was 25.1% (95% CI: 21.8%-28.5%) and of surgical TPV reintervention was 14.4% (95% CI: 11.9%-17.2%). Risk factors for surgical reintervention included age (0.95 per year [95% CI: 0.93-0.97 per year]; P < 0.001), prior endocarditis (2.5 [95% CI: 1.4-4.3]; P = 0.001), TPVR into a stented bioprosthetic valve (1.7 [95% CI: 1.2-2.5]; P = 0.007), and postimplant gradient (1.4 per 10 mm Hg [95% CI: 1.2-1.7 per 10 mm Hg]: P < 0.001).

CONCLUSIONS: These findings support the conclusion that survival and freedom from reintervention or surgery after TPVR are generally comparable to outcomes of surgical conduit/valve replacement across a wide age range.

OriginalsprogEngelsk
TidsskriftJournal of the American College of Cardiology
Vol/bind79
Udgave nummer1
Sider (fra-til)18-32
Antal sider15
ISSN0735-1097
DOI
StatusUdgivet - 4 jan. 2022

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