Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{132685fc8bf543149462ecf0d74e36ac,
title = "Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment",
abstract = "Chronic unpredictable stress (CUS) is a widely used animal model of depression. The present study was undertaken to investigate behavioral, physiological and molecular effects of CUS and/or chronic antidepressant treatment (venlafaxine or imipramine) in the same set of animals. Anhedonia, a core symptom of depression, was assessed by measuring consumption of a palatable solution. Exposure to CUS reduced intake of a palatable solution and this effect was prevented by chronic antidepressant treatment. Moreover, chronic antidepressant treatment decreased depressive-like behavior in a modified forced swim test in stressed rats. Present evidence suggests a role for brain-derived neurotrophic factor (BDNF) in depression. BDNF mRNA levels in the ventral and dorsal hippocampus were assessed by in situ hybridization. Exposure to CUS was not correlated with a decrease but rather with an increase in BDNF mRNA expression in both the dentate gyrus of the dorsal hippocampus and the CA3 region of the ventral hippocampus indicating that there is no simple link between depression-like behaviors per se and brain BDNF levels in rats. However, a significant increase in BDNF mRNA levels in the dentate gyrus of the dorsal hippocampus correlated with chronic antidepressant treatment emphasizing a role for BDNF in the mechanisms underlying antidepressant activity.",
keywords = "Animals, Antidepressive Agents, Brain-Derived Neurotrophic Factor, CA3 Region, Hippocampal, Cyclohexanols, Dentate Gyrus, Disease Models, Animal, Food Preferences, Hippocampus, Imipramine, In Situ Hybridization, Locomotion, Male, Maze Learning, RNA, Messenger, Rats, Rats, Sprague-Dawley, Saccharin, Stress, Psychological, Sweetening Agents, Swimming, Time Factors, Venlafaxine Hydrochloride, Journal Article, Research Support, Non-U.S. Gov't",
author = "Larsen, {Marianne Hald} and Mikkelsen, {Jens D} and Anders Hay-Schmidt and Carmen Sandi",
year = "2010",
month = oct,
doi = "10.1016/j.jpsychires.2010.01.005",
language = "English",
volume = "44",
pages = "808--16",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
publisher = "Pergamon",
number = "13",

}

RIS

TY - JOUR

T1 - Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment

AU - Larsen, Marianne Hald

AU - Mikkelsen, Jens D

AU - Hay-Schmidt, Anders

AU - Sandi, Carmen

PY - 2010/10

Y1 - 2010/10

N2 - Chronic unpredictable stress (CUS) is a widely used animal model of depression. The present study was undertaken to investigate behavioral, physiological and molecular effects of CUS and/or chronic antidepressant treatment (venlafaxine or imipramine) in the same set of animals. Anhedonia, a core symptom of depression, was assessed by measuring consumption of a palatable solution. Exposure to CUS reduced intake of a palatable solution and this effect was prevented by chronic antidepressant treatment. Moreover, chronic antidepressant treatment decreased depressive-like behavior in a modified forced swim test in stressed rats. Present evidence suggests a role for brain-derived neurotrophic factor (BDNF) in depression. BDNF mRNA levels in the ventral and dorsal hippocampus were assessed by in situ hybridization. Exposure to CUS was not correlated with a decrease but rather with an increase in BDNF mRNA expression in both the dentate gyrus of the dorsal hippocampus and the CA3 region of the ventral hippocampus indicating that there is no simple link between depression-like behaviors per se and brain BDNF levels in rats. However, a significant increase in BDNF mRNA levels in the dentate gyrus of the dorsal hippocampus correlated with chronic antidepressant treatment emphasizing a role for BDNF in the mechanisms underlying antidepressant activity.

AB - Chronic unpredictable stress (CUS) is a widely used animal model of depression. The present study was undertaken to investigate behavioral, physiological and molecular effects of CUS and/or chronic antidepressant treatment (venlafaxine or imipramine) in the same set of animals. Anhedonia, a core symptom of depression, was assessed by measuring consumption of a palatable solution. Exposure to CUS reduced intake of a palatable solution and this effect was prevented by chronic antidepressant treatment. Moreover, chronic antidepressant treatment decreased depressive-like behavior in a modified forced swim test in stressed rats. Present evidence suggests a role for brain-derived neurotrophic factor (BDNF) in depression. BDNF mRNA levels in the ventral and dorsal hippocampus were assessed by in situ hybridization. Exposure to CUS was not correlated with a decrease but rather with an increase in BDNF mRNA expression in both the dentate gyrus of the dorsal hippocampus and the CA3 region of the ventral hippocampus indicating that there is no simple link between depression-like behaviors per se and brain BDNF levels in rats. However, a significant increase in BDNF mRNA levels in the dentate gyrus of the dorsal hippocampus correlated with chronic antidepressant treatment emphasizing a role for BDNF in the mechanisms underlying antidepressant activity.

KW - Animals

KW - Antidepressive Agents

KW - Brain-Derived Neurotrophic Factor

KW - CA3 Region, Hippocampal

KW - Cyclohexanols

KW - Dentate Gyrus

KW - Disease Models, Animal

KW - Food Preferences

KW - Hippocampus

KW - Imipramine

KW - In Situ Hybridization

KW - Locomotion

KW - Male

KW - Maze Learning

KW - RNA, Messenger

KW - Rats

KW - Rats, Sprague-Dawley

KW - Saccharin

KW - Stress, Psychological

KW - Sweetening Agents

KW - Swimming

KW - Time Factors

KW - Venlafaxine Hydrochloride

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.jpsychires.2010.01.005

DO - 10.1016/j.jpsychires.2010.01.005

M3 - Journal article

C2 - 20172535

VL - 44

SP - 808

EP - 816

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

IS - 13

ER -

ID: 51803670