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Regional differences in turnover, composition, and mechanics of the porcine flexor tendon

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@article{b23363ad5b324ab2b6599068ff6a0f58,
title = "Regional differences in turnover, composition, and mechanics of the porcine flexor tendon",
abstract = "Purpose: Recent data suggest that there is a lack of turnover in the core of human tendon, but it remains unknown whether there are regional differences between core and periphery of the cross section. The purpose of this project was to investigate regional differences in turnover as estimated by the accumulation of fluorescent Advanced Glycation End-products (AGEs) and regional differences in mechanical properties. Materials and methods: Tendons were obtained from lean control (n = 4) and diabetic G{\"o}ttingen minipigs (streptozotocin-induced, n = 6). The deep digital flexor tendon of one hind limb was separated into a proximal, central and distal part. Autofluorescence was measured in the core and periphery of the proximal and distal parts of the tendon, and mechanical properties were tested on fascicles taken from the core and periphery of the central tendon (only diabetic animals). Results: Autofluorescence was greater in the proximal than the distal part. In the distal part of the lean control animals, autofluorescent AGE accumulation was also greater in the core than the periphery. Peak modulus in the core region (704 ± 79 MPa) was higher than the periphery (466 ± 53 MPa, p < 0.05) in diabetic tendons. Conclusion: Taken together, autofluorescence varied both along the length and across the tendon cross section, indicating higher turnover in the distal and peripheral regions. In addition, mechanical properties differed across the tendon cross-section.",
author = "Cheng Zhang and Svensson, {Rene B} and Christian Coupp{\'e} and Peter Schjerling and Dorthe Skovgaard and Michael Kjaer and Magnusson, {S Peter}",
year = "2019",
doi = "10.1080/03008207.2019.1620222",
language = "English",
journal = "Connective Tissue Research",
issn = "0300-8207",
publisher = "Informa Healthcare",

}

RIS

TY - JOUR

T1 - Regional differences in turnover, composition, and mechanics of the porcine flexor tendon

AU - Zhang, Cheng

AU - Svensson, Rene B

AU - Couppé, Christian

AU - Schjerling, Peter

AU - Skovgaard, Dorthe

AU - Kjaer, Michael

AU - Magnusson, S Peter

PY - 2019

Y1 - 2019

N2 - Purpose: Recent data suggest that there is a lack of turnover in the core of human tendon, but it remains unknown whether there are regional differences between core and periphery of the cross section. The purpose of this project was to investigate regional differences in turnover as estimated by the accumulation of fluorescent Advanced Glycation End-products (AGEs) and regional differences in mechanical properties. Materials and methods: Tendons were obtained from lean control (n = 4) and diabetic Göttingen minipigs (streptozotocin-induced, n = 6). The deep digital flexor tendon of one hind limb was separated into a proximal, central and distal part. Autofluorescence was measured in the core and periphery of the proximal and distal parts of the tendon, and mechanical properties were tested on fascicles taken from the core and periphery of the central tendon (only diabetic animals). Results: Autofluorescence was greater in the proximal than the distal part. In the distal part of the lean control animals, autofluorescent AGE accumulation was also greater in the core than the periphery. Peak modulus in the core region (704 ± 79 MPa) was higher than the periphery (466 ± 53 MPa, p < 0.05) in diabetic tendons. Conclusion: Taken together, autofluorescence varied both along the length and across the tendon cross section, indicating higher turnover in the distal and peripheral regions. In addition, mechanical properties differed across the tendon cross-section.

AB - Purpose: Recent data suggest that there is a lack of turnover in the core of human tendon, but it remains unknown whether there are regional differences between core and periphery of the cross section. The purpose of this project was to investigate regional differences in turnover as estimated by the accumulation of fluorescent Advanced Glycation End-products (AGEs) and regional differences in mechanical properties. Materials and methods: Tendons were obtained from lean control (n = 4) and diabetic Göttingen minipigs (streptozotocin-induced, n = 6). The deep digital flexor tendon of one hind limb was separated into a proximal, central and distal part. Autofluorescence was measured in the core and periphery of the proximal and distal parts of the tendon, and mechanical properties were tested on fascicles taken from the core and periphery of the central tendon (only diabetic animals). Results: Autofluorescence was greater in the proximal than the distal part. In the distal part of the lean control animals, autofluorescent AGE accumulation was also greater in the core than the periphery. Peak modulus in the core region (704 ± 79 MPa) was higher than the periphery (466 ± 53 MPa, p < 0.05) in diabetic tendons. Conclusion: Taken together, autofluorescence varied both along the length and across the tendon cross section, indicating higher turnover in the distal and peripheral regions. In addition, mechanical properties differed across the tendon cross-section.

U2 - 10.1080/03008207.2019.1620222

DO - 10.1080/03008207.2019.1620222

M3 - Journal article

JO - Connective Tissue Research

JF - Connective Tissue Research

SN - 0300-8207

ER -

ID: 58971953