Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. New drug candidates for depression - a nationwide population-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Remitted affective disorders and high familial risk of affective disorders associate with aberrant intestinal microbiota

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Electroconvulsive therapy increases brain volume in major depression: a systematic review and meta-analysis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Response to the comments on 'Continuation of lithium after a diagnosis of chronic kidney disease'

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. The validity and sensitivity of PANSS-6 in treatment-resistant schizophrenia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Neuroticism predicts the impact of serotonin challenges on fear processing in subgenual anterior cingulate cortex

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Electro convulsive therapy: Modification of its effect on the autonomic nervous system using anti-cholinergic drugs

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Low on energy? An energy supply-demand perspective on stress and depression

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
OBJECTIVE:

To investigate the role of hippocampal plasticity in the antidepressant effect of electroconvulsive therapy (ECT).

METHOD:

We used magnetic resonance (MR) imaging including diffusion tensor imaging (DTI) and proton MR spectroscopy (1 H-MRS) to investigate hippocampal volume, diffusivity, and metabolite changes in 19 patients receiving ECT for severe depression. Other regions of interest included the amygdala, dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex, and hypothalamus. Patients received a 3T MR scan before ECT (TP1), 1 week (TP2), and 4 weeks (TP3) after ECT.

RESULTS:

Hippocampal and amygdala volume increased significantly at TP2 and continued to be increased at TP3. DLPFC exhibited a transient volume reduction at TP2. DTI revealed a reduced anisotropy and diffusivity of the hippocampus at TP2. We found no significant post-ECT changes in brain metabolite concentrations, and we were unable to identify a spectral signature at ≈1.30 ppm previously suggested to reflect neurogenesis induced by ECT. None of the brain imaging measures correlated to the clinical response.

CONCLUSION:

Our findings show that ECT causes a remodeling of brain structures involved in affective regulation, but due to their lack of correlation with the antidepressant effect, this remodeling does not appear to be directly underlying the antidepressant action of ECT.
OriginalsprogEngelsk
TidsskriftActa Psychiatrica Scandinavica
Vol/bind133
Sider (fra-til)154-164
Antal sider11
ISSN0001-690X
DOI
StatusUdgivet - feb. 2016

ID: 45496881