Reference values for leptin/adiponectin ratio in healthy children and adolescents

Ulrik Lausten-Thomsen; Morten Asp Vonsild Lund; Christine Frithioff-Bøjsøe; Paula Louise Hedley; Oluf Pedersen; Torben Hansen; Michael Christiansen; Jens-Christian Holm

doi:10.1016/j.cca.2019.03.004

Reference values for leptin/adiponectin ratio in healthy children and adolescents

Ulrik Lausten-Thomsen, Morten Asp Vonsild Lund, Christine Frithioff-Bøjsøe, Paula Louise Hedley, Oluf Pedersen, Torben Hansen, Michael Christiansen, Jens-Christian Holm

Afdeling for Intensiv behandling af nyfødte og mindre børn JMC

21 Citationer (Scopus)

Abstract

BACKGROUND: Leptin and adiponectin are two key adipocyte secreted hormones and both are involved in several essential physiological mechanisms. Due to their central role in energy homeostasis their ratio, the leptin/adiponectin ratio, is believed to be a marker of metabolic derangement. Pediatric reference values are needed for the risk stratification of individual-measured ratios.

METHODS: Blood samples were drawn from healthy, Danish schoolchildren following an overnight fast. A ratio was calculated from serum leptin and adiponectin quantifications done using commercially available ELISA Kits.

RESULTS: Nine hundred eighty-three participants (583 girls) aged 6-18 years were included. Smoothed percentile curves and age-group specific percentiles were calculated. A correlation with age was demonstrated, with a gradual increase with age in girls and a negative parabolic relation, with a peak in age group 10-14, in boys. The leptin/adiponectin ratio was positively correlated to the body mass index standard deviation score for both girls and boys (p < .001).

CONCLUSION: The leptin/adiponectin ratio is correlated to age and differs between the sexes in healthy children and adolescents.

Originalsprog	Engelsk
Tidsskrift	Clinica chimica acta; international journal of clinical chemistry
Vol/bind	493
Sider (fra-til)	123-128
Antal sider	6
ISSN	0009-8981
DOI	https://doi.org/10.1016/j.cca.2019.03.004
Status	Udgivet - jun. 2019

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title = "Reference values for leptin/adiponectin ratio in healthy children and adolescents",

abstract = "BACKGROUND: Leptin and adiponectin are two key adipocyte secreted hormones and both are involved in several essential physiological mechanisms. Due to their central role in energy homeostasis their ratio, the leptin/adiponectin ratio, is believed to be a marker of metabolic derangement. Pediatric reference values are needed for the risk stratification of individual-measured ratios.METHODS: Blood samples were drawn from healthy, Danish schoolchildren following an overnight fast. A ratio was calculated from serum leptin and adiponectin quantifications done using commercially available ELISA Kits.RESULTS: Nine hundred eighty-three participants (583 girls) aged 6-18 years were included. Smoothed percentile curves and age-group specific percentiles were calculated. A correlation with age was demonstrated, with a gradual increase with age in girls and a negative parabolic relation, with a peak in age group 10-14, in boys. The leptin/adiponectin ratio was positively correlated to the body mass index standard deviation score for both girls and boys (p < .001).CONCLUSION: The leptin/adiponectin ratio is correlated to age and differs between the sexes in healthy children and adolescents.",

keywords = "Adiponectin/blood, Adolescent, Body Mass Index, Child, Female, Humans, Leptin/blood, Male, Reference Values",

author = "Ulrik Lausten-Thomsen and Lund, \{Morten Asp Vonsild\} and Christine Frithioff-B{\o}js{\o}e and Hedley, \{Paula Louise\} and Oluf Pedersen and Torben Hansen and Michael Christiansen and Jens-Christian Holm",

note = "Copyright {\textcopyright} 2019. Published by Elsevier B.V.",

year = "2019",

month = jun,

doi = "10.1016/j.cca.2019.03.004",

language = "English",

volume = "493",

pages = "123--128",

journal = "Clinica chimica acta; international journal of clinical chemistry",

issn = "0009-8981",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Reference values for leptin/adiponectin ratio in healthy children and adolescents

AU - Lausten-Thomsen, Ulrik

AU - Lund, Morten Asp Vonsild

AU - Frithioff-Bøjsøe, Christine

AU - Hedley, Paula Louise

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Christiansen, Michael

AU - Holm, Jens-Christian

PY - 2019/6

Y1 - 2019/6

N2 - BACKGROUND: Leptin and adiponectin are two key adipocyte secreted hormones and both are involved in several essential physiological mechanisms. Due to their central role in energy homeostasis their ratio, the leptin/adiponectin ratio, is believed to be a marker of metabolic derangement. Pediatric reference values are needed for the risk stratification of individual-measured ratios.METHODS: Blood samples were drawn from healthy, Danish schoolchildren following an overnight fast. A ratio was calculated from serum leptin and adiponectin quantifications done using commercially available ELISA Kits.RESULTS: Nine hundred eighty-three participants (583 girls) aged 6-18 years were included. Smoothed percentile curves and age-group specific percentiles were calculated. A correlation with age was demonstrated, with a gradual increase with age in girls and a negative parabolic relation, with a peak in age group 10-14, in boys. The leptin/adiponectin ratio was positively correlated to the body mass index standard deviation score for both girls and boys (p < .001).CONCLUSION: The leptin/adiponectin ratio is correlated to age and differs between the sexes in healthy children and adolescents.

AB - BACKGROUND: Leptin and adiponectin are two key adipocyte secreted hormones and both are involved in several essential physiological mechanisms. Due to their central role in energy homeostasis their ratio, the leptin/adiponectin ratio, is believed to be a marker of metabolic derangement. Pediatric reference values are needed for the risk stratification of individual-measured ratios.METHODS: Blood samples were drawn from healthy, Danish schoolchildren following an overnight fast. A ratio was calculated from serum leptin and adiponectin quantifications done using commercially available ELISA Kits.RESULTS: Nine hundred eighty-three participants (583 girls) aged 6-18 years were included. Smoothed percentile curves and age-group specific percentiles were calculated. A correlation with age was demonstrated, with a gradual increase with age in girls and a negative parabolic relation, with a peak in age group 10-14, in boys. The leptin/adiponectin ratio was positively correlated to the body mass index standard deviation score for both girls and boys (p < .001).CONCLUSION: The leptin/adiponectin ratio is correlated to age and differs between the sexes in healthy children and adolescents.

KW - Adiponectin/blood

KW - Adolescent

KW - Body Mass Index

KW - Child

KW - Female

KW - Humans

KW - Leptin/blood

KW - Male

KW - Reference Values

UR - https://www.scopus.com/pages/publications/85062588031

U2 - 10.1016/j.cca.2019.03.004

DO - 10.1016/j.cca.2019.03.004

M3 - Journal article

C2 - 30849308

SN - 0009-8981

VL - 493

SP - 123

EP - 128

JO - Clinica chimica acta; international journal of clinical chemistry

JF - Clinica chimica acta; international journal of clinical chemistry

ER -

Reference values for leptin/adiponectin ratio in healthy children and adolescents

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