Reduced levels of pulmonary surfactant in COVID-19 ARDS

Peter Schousboe, Andreas Ronit, Henning B Nielsen, Thomas Benfield, Lothar Wiese, Nikolaos Scoutaris, Henrik Verder, Ronan M G Berg, Povl Verder, Ronni R Plovsing

18 Citationer (Scopus)

Abstract

To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.

OriginalsprogEngelsk
Artikelnummer4040
TidsskriftScientific Reports
Vol/bind12
Udgave nummer1
Sider (fra-til)1-5
Antal sider5
ISSN2045-2322
DOI
StatusUdgivet - 8 mar. 2022

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