Reduced levels of pulmonary surfactant in COVID-19 ARDS

Peter Schousboe; Andreas Ronit; Henning B Nielsen; Thomas Benfield; Lothar Wiese; Nikolaos Scoutaris; Henrik Verder; Ronan M G Berg; Povl Verder; Ronni R Plovsing

doi:10.1038/s41598-022-07944-4

Reduced levels of pulmonary surfactant in COVID-19 ARDS

Peter Schousboe, Andreas Ronit, Henning B Nielsen, Thomas Benfield, Lothar Wiese, Nikolaos Scoutaris, Henrik Verder, Ronan M G Berg, Povl Verder, Ronni R Plovsing

23 Citationer (Scopus)

Abstract

To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.

Originalsprog	Engelsk
Artikelnummer	4040
Tidsskrift	Scientific Reports
Vol/bind	12
Udgave nummer	1
Sider (fra-til)	1-5
Antal sider	5
ISSN	2045-2322
DOI	https://doi.org/10.1038/s41598-022-07944-4
Status	Udgivet - 8 mar. 2022

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title = "Reduced levels of pulmonary surfactant in COVID-19 ARDS",

abstract = "To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.",

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AU - Nielsen, Henning B

AU - Benfield, Thomas

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AU - Scoutaris, Nikolaos

AU - Verder, Henrik

AU - Berg, Ronan M G

AU - Verder, Povl

AU - Plovsing, Ronni R

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Reduced levels of pulmonary surfactant in COVID-19 ARDS

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